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Laminins and the blood-brain barrier
Matrix BiologyThe blood-brain barrier (BBB) is a dynamic structure that maintains brain homeostasis. BBB breakdown is a key pathological hallmark of almost all neurological diseases. Although the regulation of BBB integrity by different cells has been extensively studied, the function of its non-cellular component-the basal lamina in BBB regulation remains largely ...
Ava Nasrollahi, Yao Yao
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The Blood–Brain Barrier and Epilepsy
Epilepsia, 2006Summary: During the past several years, there has been increasing interest in the role of the blood–brain barrier (BBB) in epilepsy. Advances in neuroradiology have enhanced our ability to image and study the human cerebrovasculature, and further developments in the research of metabolic deficiencies linked to seizure disorders (e.g., GLUT1 deficiency)
Emily, Oby, Damir, Janigro
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Blood-Brain Barrier for Adrenaline
Science, 1959The concentration of tritium-labeled adrenaline was determined in various areas of cat brain after intravenous infusion. It did not exceed that expected from the blood content of the tissue except in the hypothalamus, where small but significant amounts of H 3 -adrenaline were found.
H, WEIL-MALHERBE +2 more
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The Blood-Brain Barrier in Hypoxia
International Journal of Sports Medicine, 1992The concept of blood-brain barrier has moved over the past years from a passive and relatively immutable structure to a more dynamic interface between blood and brain tissue. The transport mechanisms regulating this adaptative interface might be considered as the most sensitive elements to change such as hypoxia.
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Goldthioglucose and the blood-brain barrier
Experientia, 1968Apres avoir augmente la permeabilite corticale sang-cerveau chez des rats, on a donne a ces animaux une injection d'aurothioglucose. Aucune lesion due a l'aurothioglucose n'a ete decouverte dans aucun des sites de permeabilite accrue. Les resultats montrent que la production de lesions par l'aurothioglucose n'est pas due a une permeabilite non ...
E A, Arees, J, Mayer
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Journal of neuroradiology = Journal de neuroradiologie, 1990
The blood-brain barrier (BBB) is present on three sites: the brain vessels, the choroid plexus and the arachnoid membrane. It is made of non-fenestrated endothelial or epithelial cells interconnected by tight junctions. Biochemically, the BBB is formed by bimolecular layers of phospholipids into which globular proteins are inserted.
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The blood-brain barrier (BBB) is present on three sites: the brain vessels, the choroid plexus and the arachnoid membrane. It is made of non-fenestrated endothelial or epithelial cells interconnected by tight junctions. Biochemically, the BBB is formed by bimolecular layers of phospholipids into which globular proteins are inserted.
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Insulin and the Blood-Brain Barrier
Current Pharmaceutical Design, 2003Although several possible mechanisms exist by which the pancreatic hormone, insulin, could enter the brain from the blood, most evidence suggests that the majority of it enters primarily by a receptor-mediated transport process. Many factors influence the rate of entry, including fasting and refeeding and several pathological conditions.
Stephen C, Woods +3 more
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Blood-brain barrier biomarkers
The blood-brain barrier (BBB) is a dynamic interface that regulates the exchange of molecules and cells between the brain parenchyma and the peripheral blood. The BBB is mainly composed of endothelial cells, astrocytes and pericytes. The integrity of this structure is essential for maintaining brain and spinal cord homeostasis and protection from ...Juan F, Zapata-Acevedo +3 more
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The blood-brain barrier and aids
2001Publisher Summary This chapter focuses on how human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) are proposed to interact with and cross the blood–brain barrier (BBB) and to effect central nervous system (CNS) damage. The CNS as a reservoir of virus and the BBB as a limitation to the eradication of HIV are discussed.
L I, Strelow, D, Janigro, J A, Nelson
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