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The Blood-Brain Barrier in Hypoxia
International Journal of Sports Medicine, 1992The concept of blood-brain barrier has moved over the past years from a passive and relatively immutable structure to a more dynamic interface between blood and brain tissue. The transport mechanisms regulating this adaptative interface might be considered as the most sensitive elements to change such as hypoxia.
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MIGRAINE AND THE BLOOD-BRAIN BARRIER
The Lancet, 1977The prodromal (cerebral) symptoms of migraine are associated with a fall in cerebral blood-flow (C.B.F.). The suggestion that various circulating vasoactive agents might be the cause of this fall in C.B.F. ignores the contradictory findings that the cerebral vascular bed is normally unresponsive to such agents; but if the blood-barrier is disrupted ...
A M, Harper +3 more
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Goldthioglucose and the blood-brain barrier
Experientia, 1968Apres avoir augmente la permeabilite corticale sang-cerveau chez des rats, on a donne a ces animaux une injection d'aurothioglucose. Aucune lesion due a l'aurothioglucose n'a ete decouverte dans aucun des sites de permeabilite accrue. Les resultats montrent que la production de lesions par l'aurothioglucose n'est pas due a une permeabilite non ...
E A, Arees, J, Mayer
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Development of the blood-brain barrier
Trends in Neurosciences, 1990The microenvironment of the CNS is important for neuronal function, and the blood-brain barrier is involved in its maintenance. The barrier is present in a complex cellular system at the level of the tight junctions between endothelial cells. The unique properties of the endothelial cells in the CNS compared with those present in other organs are not ...
W, Risau, H, Wolburg
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Laminins and the blood-brain barrier
Matrix BiologyThe blood-brain barrier (BBB) is a dynamic structure that maintains brain homeostasis. BBB breakdown is a key pathological hallmark of almost all neurological diseases. Although the regulation of BBB integrity by different cells has been extensively studied, the function of its non-cellular component-the basal lamina in BBB regulation remains largely ...
Ava Nasrollahi, Yao Yao
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Blood-Brain Barrier for Adrenaline
Science, 1959The concentration of tritium-labeled adrenaline was determined in various areas of cat brain after intravenous infusion. It did not exceed that expected from the blood content of the tissue except in the hypothalamus, where small but significant amounts of H 3 -adrenaline were found.
H, WEIL-MALHERBE +2 more
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Journal of neuroradiology = Journal de neuroradiologie, 1990
The blood-brain barrier (BBB) is present on three sites: the brain vessels, the choroid plexus and the arachnoid membrane. It is made of non-fenestrated endothelial or epithelial cells interconnected by tight junctions. Biochemically, the BBB is formed by bimolecular layers of phospholipids into which globular proteins are inserted.
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The blood-brain barrier (BBB) is present on three sites: the brain vessels, the choroid plexus and the arachnoid membrane. It is made of non-fenestrated endothelial or epithelial cells interconnected by tight junctions. Biochemically, the BBB is formed by bimolecular layers of phospholipids into which globular proteins are inserted.
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A blood-brain barrier in a dish
Nature Methods, 2012Codifferentiating human pluripotent stem cells along neural and endothelial lineages provides cues to efficiently generate blood-brain barrier endothelial cells.
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Blood-brain barrier biomarkers
The blood-brain barrier (BBB) is a dynamic interface that regulates the exchange of molecules and cells between the brain parenchyma and the peripheral blood. The BBB is mainly composed of endothelial cells, astrocytes and pericytes. The integrity of this structure is essential for maintaining brain and spinal cord homeostasis and protection from ...Juan F, Zapata-Acevedo +3 more
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Drug Discovery Today, 2007
Neuropharmaceutics is the largest potential growth sector of the pharmaceutical industry. However, this growth is blocked by the problem of the blood-brain barrier (BBB). Essentially 100% of large-molecule drugs and >98% of small-molecule drugs do not cross the BBB. The BBB can be traversed because there are multiple endogenous transporters within this
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Neuropharmaceutics is the largest potential growth sector of the pharmaceutical industry. However, this growth is blocked by the problem of the blood-brain barrier (BBB). Essentially 100% of large-molecule drugs and >98% of small-molecule drugs do not cross the BBB. The BBB can be traversed because there are multiple endogenous transporters within this
openaire +2 more sources