Results 301 to 310 of about 792,108 (354)
Some of the next articles are maybe not open access.
From blood–brain barrier to blood–brain interface: new opportunities for CNS drug delivery
Nature Reviews Drug Discovery, 2016William A Banks, Banks William A
exaly +2 more sources
Journal of Neuroimmune Pharmacology, 2013
The concept of a blood-brain barrier (BBB) dates back to experiments performed by Paul Ehrlich. Using "intravital tracers" which change their color depending on their oxidative state, he intended to estimate the oxygen consumption of the bodily organs.
Felix, Dyrna +3 more
openaire +2 more sources
The concept of a blood-brain barrier (BBB) dates back to experiments performed by Paul Ehrlich. Using "intravital tracers" which change their color depending on their oxidative state, he intended to estimate the oxygen consumption of the bodily organs.
Felix, Dyrna +3 more
openaire +2 more sources
2016
In autoimmune neurologic disorders, the blood-brain barrier (BBB) plays a central role in immunopathogenesis, since this vascular interface is an entry path for cells and effector molecules of the peripheral immune system to reach the target organ, the central nervous system (CNS). The BBB's unique anatomic structure and the tightly regulated interplay
Birgit, Obermeier +2 more
openaire +2 more sources
In autoimmune neurologic disorders, the blood-brain barrier (BBB) plays a central role in immunopathogenesis, since this vascular interface is an entry path for cells and effector molecules of the peripheral immune system to reach the target organ, the central nervous system (CNS). The BBB's unique anatomic structure and the tightly regulated interplay
Birgit, Obermeier +2 more
openaire +2 more sources
Neurosurgery, 1980
The anatomical component of the blood-brain barrier (BBB) has been shown to be the cerebral capillary. These capillary endothelial cells are connected by continuous tight intercellular junctions and under normal conditions do not demonstrate transendothelial channels or pinocytotic vesicles.
M, Pollay, P A, Roberts
openaire +2 more sources
The anatomical component of the blood-brain barrier (BBB) has been shown to be the cerebral capillary. These capillary endothelial cells are connected by continuous tight intercellular junctions and under normal conditions do not demonstrate transendothelial channels or pinocytotic vesicles.
M, Pollay, P A, Roberts
openaire +2 more sources
Experimental Eye Research, 1977
The concept of a barrier restricting exchange of certain tracer substances between blood and brain (the blood-barrier, BBB) originated with Paul Ehrlich’s observation in the 1880’s that intravenously injected aniline dyes failed to distribute to brain, whereas all other tissues were quickly colored.
openaire +2 more sources
The concept of a barrier restricting exchange of certain tracer substances between blood and brain (the blood-barrier, BBB) originated with Paul Ehrlich’s observation in the 1880’s that intravenously injected aniline dyes failed to distribute to brain, whereas all other tissues were quickly colored.
openaire +2 more sources
Adrenomedullin and the Blood-Brain Barrier
Hormone and Metabolic Research, 2001Adrenomedullin (ADM) is present both in the periphery and brain. In addition to its peripheral effects, this peptide can exert central effects such as decreasing food ingestion. We used multiple-time regression analysis to determine that labeled ADM can cross from blood to brain with an apparent influx constant (K(I)) of 5.83 +/- 1.44 x 10(-4) ml/g-min,
A J, Kastin +3 more
openaire +2 more sources
The Blood–Brain Barrier and Epilepsy
Epilepsia, 2006Summary: During the past several years, there has been increasing interest in the role of the blood–brain barrier (BBB) in epilepsy. Advances in neuroradiology have enhanced our ability to image and study the human cerebrovasculature, and further developments in the research of metabolic deficiencies linked to seizure disorders (e.g., GLUT1 deficiency)
Emily, Oby, Damir, Janigro
openaire +2 more sources
The blood–brain barrier: a help and a hindrance
Brain : a journal of neurologyThe blood–brain barrier (BBB) is a specialized vascular structure that protects the brain micro-environment from toxins and pathogens in the blood. At the same time, the BBB presents a significant challenge for drug development, as it restricts the entry
Ruslan Rust +4 more
semanticscholar +1 more source
Bypassing the blood-brain barrier
Science, 2019The meninges membranes surrounding the brain are an immune-blood-brain interface in homeostasis and ...
Justin, Rustenhoven, Jonathan, Kipnis
openaire +2 more sources
Current Biology
In animals, the central nervous system (CNS) plays a crucial role as the primary organ responsible for integrating environmental information and coordinating the responses of the organism. To protect its intricate and delicate structure, the CNS is enclosed within the rigid confines of the skull, an effective defence against physical trauma.
Audrey, Chagnot, Axel, Montagne
openaire +2 more sources
In animals, the central nervous system (CNS) plays a crucial role as the primary organ responsible for integrating environmental information and coordinating the responses of the organism. To protect its intricate and delicate structure, the CNS is enclosed within the rigid confines of the skull, an effective defence against physical trauma.
Audrey, Chagnot, Axel, Montagne
openaire +2 more sources