Results 111 to 120 of about 3,752,555 (313)
DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated‐Acute Kidney Injury
Advanced Science, EarlyView.This study identifies a potential therapeutic approach for sepsis‐associated acute kidney injury (SA‐AKI). We found that during SA‐AKI, reduced expression of DDX3x in renal tubular epithelial cells mediates histone delactylation, which in turn upregulates NINJ1 transcription and triggers tubular cell death. Conversely, Odetiglucan confers protection by
Hongyu Liang +7 more
wiley +1 more source
Journal of Feline Medicine and Surgery Open Reports, 2017 Objectives The objective of this study was to document the prevalence of feline blood types in the Iberian Peninsula and to determine the potential risk of incompatibility-related transfusion reactions in unmatched transfusions and the potential risk of ...
Sandrina M Vieira +8 more
doaj +1 more source
IDB Newsletter: Vol. 7, no. 2, April 1969
, 1969 IDB Newsletter is a monthly publication of the Inter-American Development that reports on the activities of the Inter-American Development Bank and appears in English and Spanish ...
Inter-American Development Bank
core +1 more source
Advanced Science, EarlyView.HOXC11 drives colorectal cancer progression by transcriptionally activating CAMK2A, which triggers NF‐κB–dependent CXCL5 upregulation. CXCL5–CXCR2 signaling further reinforces HOXC11 expression through the ERK1/2–SP1 axis, forming a prometastatic positive feedback loop that is effectively disrupted by combined CAMK2A and CXCR2 inhibition.
Qingyang Sun +12 more
wiley +1 more source
IDB Newsletter: Vol. 2, no. 1, January 1964
, 1964 IDB Newsletter is a monthly publication of the Inter-American Development that reports on the activities of the Inter-American Development Bank and appears in English and Spanish ...
Inter-American Development Bank
core +1 more source
Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy
Advanced Science, EarlyView.By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng +16 more
wiley +1 more source
IDB Newsletter: Vol. 6, no. 4, October 1968
, 1968 IDB Newsletter is a monthly publication of the Inter-American Development that reports on the activities of the Inter-American Development Bank and appears in English and Spanish ...
Inter-American Development Bank
core +1 more source
Advanced Science, EarlyView.A mitochondria‐derived tRNA half, mt‐5’‐tiRNA‐Tyr, is upregulated in colorectal cancer tissues and plasma and promotes tumor proliferation. It binds HARS2 and promotes CPT1A‐associated HARS2 K91 succinylation, disrupts HARS2–mt‐tRNA‐His association, impairs mitochondrial translation, enhances succinate‐linked metabolic reprogramming, and shows promise ...
Xinliang Gu +10 more
wiley +1 more source
IDB Newsletter: Vol. 8, no. 4, October 1970
, 1970 IDB Newsletter is a monthly publication of the Inter-American Development that reports on the activities of the Inter-American Development Bank and appears in English and Spanish ...
Inter-American Development Bank
core +1 more source
Advanced Science, EarlyView.LDHA‐driven lactate production in mesenchymal glioma stem cells promotes p300‐dependent H3K18 lactylation, activates USP30 transcription, and stabilizes MBOAT2 to remodel phosphatidylethanolamines toward ferroptosis‐resistant PE‐MUFA species. Disrupting this metabolic–epigenetic–lipid circuit enhances ferroptosis and sensitizes glioblastoma to ...
Zong Miao +13 more
wiley +1 more source