Results 1 to 10 of about 4,638,350 (355)

Cell therapies in the clinic

Bioengineering & Translational Medicine, 2021
Cell therapies have emerged as a promising therapeutic modality with the potential to treat and even cure a diverse array of diseases. Cell therapies offer unique clinical and therapeutic advantages over conventional small molecules and the growing ...
Lily Li‐Wen Wang, Morgan E. Janes, Ninad Kumbhojkar, Neha Kapate, John R. Clegg, Supriya Prakash, Mairead K. Heavey, Zongmin Zhao, Aaron C. Anselmo, Samir Mitragotri   +9 more
doaj   +1 more source

Effect of mycophenolate mofetil on the white blood cell count and the frequency of infection in systemic lupus erythematosus. [PDF]

, 2015
Leukopenia is a common manifestation of SLE. Addition of immunosuppressive therapy in a SLE patient who is already leukopenic is a clinical concern. It could worsen leukopenia, increase the risk of infection, or both. The aim of this study was to analyze
Magder, Laurence S., Petri, Michelle, Subedi, Ananta   +2 more
core   +2 more sources

Transcriptomic data from two primary cell models stimulating human monocytes suggest inhibition of oxidative phosphorylation and mitochondrial function by N. meningitidis which is partially up-regulated by IL-10

BMC Immunology, 2017
Background Biological interpretation of DNA microarray data may differ depending on underlying assumptions and statistical tests of bioinformatics tools used.
Unni Gopinathan, Reidun Øvstebø, Berit Sletbakk Brusletto, Ole Kristoffer Olstad, Peter Kierulf, Petter Brandtzaeg, Jens Petter Berg   +6 more
doaj   +1 more source

Rapid and label-free identification of single leukemia cells from blood in a high-density microfluidic trapping array by fluorescence lifetime imaging microscopy. [PDF]

, 2018
The rapid screening and isolation of single leukemia cells from blood has become critical for early leukemia detection and tumor heterogeneity interrogation. However, due to the size overlap between leukemia cells and the more abundant white blood cells (
Digman, Michelle A, Lee, Abraham P, Lee, Do-Hyun, Li, Xuan, Ma, Ning   +4 more
core   +1 more source

Milieu-adopted in vitro and in vivo differentiation of mesenchymal tissues derived from different adult human CD34-negative progenitor cell clones [PDF]

, 2005
Adult mesenchymal stem cells with multilineage differentiation potentially exist in the bone marrow, but have also been isolated from the peripheral blood.
Huss, R., Hutter, J., Krombach, F., Moosmann, S., Moser, C.   +4 more
core   +1 more source

Noncanonical Transmission of a Measles Virus Vaccine Strain from Neurons to Astrocytes

mBio, 2021
Viruses are the most important cause of infectious encephalitis in mammals worldwide; several thousand people, primarily the very young and the elderly, are impacted annually, and few therapies are reliably successful once neuroinvasion has occurred.
Katrien C. K. Poelaert, Riley M. Williams, Christine M. Matullo, Glenn F. Rall   +3 more
doaj   +1 more source

An Imaging Flow Cytometry Method to Measure Citrullination of H4 Histone as a Read-out for Neutrophil Extracellular Traps Formation

Bio-Protocol, 2021
The formation of neutrophil extracellular traps (NETs) is thought to play a critical role in infections and propagating sterile inflammation. Histone citrullination is an essential and early step in NETs formation, detectable prior to the formation of ...
Emilia Barbu, Venina Dominical, Laurel Mendelsohn, Swee Lay Thein   +3 more
doaj   +1 more source

Rare-cell enrichment by a rapid, label-free, ultrasonic isopycnic technique for medical diagnostics [PDF]

, 2014
One significant challenge in medical diagnostics lies in the development of label-free methods to separate different cells within complex biological samples.
Bell, Bourquin, Chappuis, Franke, Friend, Grover, Kumar, Leif, Lejon, Minion, Nash, Raghavan, Reboud, Rogers, Tan, Urdea, Wilson, Yager, Yatsushiro   +18 more
core   +1 more source

Bloodstream infections due to Carbapenem-Resistant Enterobacteriaceae in hematological patients: assessment of risk factors for mortality and treatment options

Annals of Clinical Microbiology and Antimicrobials, 2023
Purpose Bloodstream infection (BSI) caused by Carbapenem-Resistant Enterobacteriaceae (CRE) are associated with poor outcomes in hematological patients.
Lining Zhang, Sisi Zhen, Yuyan Shen, Tingting Zhang, Jieru Wang, Jia Li, Qingsong Lin, Zhijian Xiao, Yizhou Zheng, Erlie Jiang, Mingzhe Han, Jianxiang Wang, Sizhou Feng   +12 more
doaj   +1 more source

Clinical relevance of silent red blood cell autoantibodies. [PDF]

, 2017
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Alessandri, C, Caputo, Md, Colafigli, G, Coluzzi, S, De Propris, Ms, Foà, R, Giovannetti, G, Girelli, G, Guarini, Ar, Mauro, Fr, Pepe, S, Porrazzo, M, Riemma, C, Trastulli, F, Valesini, G   +14 more
core   +1 more source