Results 171 to 180 of about 17,644,374 (381)
Evaluation and modification of tumor cell isolation techniques from malignant effusions for rapid drug sensitivity testing
Molecular Oncology, EarlyView.Non‐small cell lung cancer targeted treatment is limited to a few known genetic alterations, with few alternatives in advanced treatment lines. To direct treatment decisions by drug sensitivity testing (DST), this study compared several methods for tumor cell isolation from malignant effusions, pointing to repeated CD45+ cell depletion for effective ...Navit Mooshayef, Hana Barhom, Sumit Chatterji, Netta Hecht, Oran Warhaftig, Iris Kamer, Oranit Zadok, Jair Bar, Limor Broday, Amir Onn, Michael Peled +10 morewiley +1 more sourceNovel CD123×CD33 bicistronic chimeric antigen receptor (CAR)‐T therapy has potential to reduce escape from single‐target CAR‐T with no more hematotoxicity
Cancer Communications, 2023 Zhenzhen Wang, Yang Lu, Yu Liu, Junli Mou, Xiaoyu Liu, Manling Chen, Ying Wang, Yingxi Xu, Qing Rao, Haiyan Xing, Kejing Tang, Zheng Tian, Bing Wang, Wei Qi, Min Wang, Shaowei Qiu, Dongsheng Xiong, Jianxiang Wang +17 moredoaj +1 more sourceAmphiregulin as a biomarker for monitoring lifethreatening acute graft-versus-host disease: secondary analysis of two prospective clinical trials
Haematologica, 2023 Shernan G. Holtan, Najla El Jurdi, Armin Rashidi, Brian C. Betts, Connor Demorest, John P Galvin, Margaret L. MacMillan, Daniel J. Weisdorf, Angela Panoskaltsis-Mortari, Michael A. Pratta +9 moredoaj +1 more sourceCytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models
Molecular Oncology, EarlyView.Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén +13 morewiley +1 more sourceMechanisms of red blood cell transfusion‐related immunomodulation
Transfusion, 2018 Kenneth E. Remy, M. Hall, J. Cholette, N. Juffermans, K. Nicol, A. Doctor, N. Blumberg, P. Spinella, P. Norris, M. Dahmer, J. Muszynski +10 moresemanticscholar +1 more sourceEndoglin mediates the tumor‐ and metastasis‐promoting traits of stromal myofibroblasts in human breast carcinomas
Molecular Oncology, EarlyView.Carcinoma‐associated fibroblasts (CAFs) in tumors influence cancer progression. We identified endoglin (ENG) as a key factor in TGF‐β signaling in myofibroblastic CAFs (myCAFs), linked to poor breast cancer outcomes. Inhibiting ENG on myCAFs suppressed the TGF‐β‐Smad2/3 pathway, reducing primary tumor growth and metastasis.Shoki Okubo, Yoshihiro Mezawa, Zixu Wang, Ahmet Acar, Yasuhiko Ito, Atsushi Takano, Yohei Miyagi, Tomoyuki Yokose, Toshinari Yamashita, Yataro Daigo, Takuya Shirakihara, Akira Orimo +11 morewiley +1 more source