Results 341 to 350 of about 17,462,775 (406)

A Novel CHMP2B Splicing Variant in Atypical Presentation of Familial Frontotemporal Lobar Degeneration

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT C‐truncating variants in the charged multivesicular body protein 2B (CHMP2B) gene are a rare cause of frontotemporal lobar degeneration (FTLD), previously identified only in Denmark, Belgium, and China. We report a novel CHMP2B splice‐site variant (c.35‐1G>A) associated with familial FTLD in Spain. The cases were two monozygotic male twins who
Sara Rubio‐Guerra, Sara Bernal, David Almenta, Josefina Pérez‐Blanco, Valle Camacho, Isabel Sala, Mª Belén Sánchez‐Saudinós, Jesús García Castro, Judit Selma‐González, Miguel Ángel Santos‐Santos, Álvaro Carbayo, Janina Turon‐Sans, Ricard Rojas‐Garcia, Daniel Alcolea, Juan Fortea, Alberto Lleó, Oriol Dols‐Icardo, Ignacio Illán‐Gala   +17 more
wiley   +1 more source

The circulatory dynamics of human red blood cell homeostasis: Oxy-deoxy and PIEZO1-triggered changes. [PDF]

Biophys J
Lew VL.
europepmc   +1 more source

Development of a Disease Model for Predicting Postoperative Delirium Using Combined Blood Biomarkers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Postoperative delirium, a common neurocognitive complication after surgery and anesthesia, requires early detection for potential intervention. Herein, we constructed a multidimensional postoperative delirium risk‐prediction model incorporating multiple demographic parameters and blood biomarkers to enhance prediction accuracy ...
Hengjun Wan, Huaju Tian, Cheng Wu, Yue Zhao, Daiying Zhang, Yujie Zheng, Yuan Li, Xiaoxia Duan   +7 more
wiley   +1 more source

Impacts of red blood cell suspension storage on pediatric outcomes: pediatric medicine and pediatric surgery. [PDF]

Transl Pediatr
Yin M, Bai G, Zhong Y, Ma J, Tian D, Guo X, Zhou C, Chen B, Chen X, Gao Z.   +9 more
europepmc   +1 more source

Phase 1, First‐In‐Human, Single‐/Multiple‐Ascending Dose Study of Iluzanebart in Healthy Volunteers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of iluzanebart, a fully human monoclonal antibody TREM2 (triggering receptor expressed on myeloid cells 2) agonist, after single‐ (SAD) and multiple‐ascending‐dose (MAD) administration.
Andreas Meier, Spyros Papapetropoulos, Andrew Marsh, Kelly Neelon, David Stiles, Ryan O'Mara, Evan A. Thackaberry, Marco Colonna, Raj Rajagovindan   +8 more
wiley   +1 more source

COVID- 19 in patients affected by red blood cell disorders, results from the European registry ERN-EuroBloodNet. [PDF]

Orphanet J Rare Dis
Velasco Puyo P, Christou S, Campisi S, Rodríguez-Sánchez MA, Reidel S, Perez-Hoyo S, Mota M, Savvidou I, Rekleiti A, Salvo A, Voi V, Ferrero GB, Mandrile G, Gaglioti CM, Cela E, Ponce-Salas B, Bardón-Cancho EJ, Flevari P, Voskaridou-Dimoula E, Nur E, Biemond BJ, Delaporta P, Beneitez-Pastor D, Collado Gimbert A, Spasiano A, Besse-Hammer T, Lafiatis IG, Dedeken L, Raso S, Ruiz-Llobet A, Bagnato S, Labarque V, Glenthøj A, Ruffo GB, Guerzoni ME, Hafraoui K, Pistoia L, Rosso R, Tagliaferri L, Gonzalez-Urdiales P, Benghiat FS, de Montalembert M, Teles MJ, Vanderfaeillie A, Bertoni E, Cuzzubbo D, Ferreira T, Saunders CJ, Stiakaki E, Van de Velde AL, Diamantidis MD, Kerkhoffs JH, Oliveira MI, Quota A, Russo R, Van Damme A, Argüello Marina M, Lorite Reggiori M, Rijneveld AW, Rodríguez Gallego A, Colombatti R, Iolascon A, Taher A, Gulbis B, Roy NBA, Mañú-Pereira MDM.   +65 more
europepmc   +1 more source

Reconstitution of CXCR3+ CCR6+ Th17.1‐Like T Cells in Response to Ofatumumab Therapy in Patients With Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Ofatumumab, a fully human anti‐CD20 monoclonal antibody, is effective in reducing relapses and disability progression in patients with multiple sclerosis. This study aimed to examine immune profile changes associated with ofatumumab in a prospective cohort of Chinese patients with relapsing–remitting multiple ...
Shu Yang, Tian‐Xiang Zhang, Jia Liu, Zhirui Liu, Lijie Zhu, Yan‐Yan Li, Bin Feng, Moli Fan, Fu‐Dong Shi, Chao Zhang   +9 more
wiley   +1 more source

m6A-related genes of peripheral white blood cell in spinal cord injury as potential targets for prognosis and treatment. [PDF]

Front Med (Lausanne)
Luo M, Wang Q, Chen J, Yin G.
europepmc   +1 more source

CSF Tau Is a Biomarker of Hippocampal Injury in Cryptogenic New‐Onset Refractory Status Epilepticus

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cryptogenic new‐onset refractory status epilepticus (cNORSE) is a devastating condition characterized by the de novo onset of status epilepticus with unclear etiology. The identification of relevant early biomarkers in cNORSE is important to elucidate pathophysiology, aid clinical decision‐making, and prognosticate outcomes in cNORSE.
Yihui Goh, Yoonhyuk Jang, Soo Jean Shin, Soo Hyun Ahn, Su Yee Mon, Yoon Hee Shin, Kon Chu, Sang Kun Lee, Soon‐Tae Lee   +8 more
wiley   +1 more source

Red blood cell lipid distribution in the pathophysiology and laboratory evaluation of chorea-acanthocytosis and McLeod syndrome patients. [PDF]

Front Physiol
Cloos AS, Ghodsi M, Stommen A, Recktenwald SM, Kaestner L, Danek A, Spranger A, Hermann A, Peikert K, Tyteca D.   +9 more
europepmc   +1 more source