Structural biology of ferritin nanocages
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
What is the origin of the normal ranges of blood cell counts? An evolutionary perspective
Background The normal values of the complete blood count are part of the foundational medical knowledge that is seldom questioned due to their well‐established nature.
Manon Zala +3 more
doaj +1 more source
Runting Li,1 Yuanli Zhao,1– 4 Xiaolin Chen,1,3,4 Qiang Hao1 1Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, People’s Republic of China; 2China National Clinical Research Center for Neurological Diseases ...
Li R, Zhao Y, Chen X, Hao Q
doaj
Background: Cord blood transplant is an accepted treatment for many malignant and non-malignant diseases. We sought to determine the feasibility of collecting cord blood in Jordan and the effect of maternal and fetal factors on the quality of the cord ...
Ayad Ahmed Hussein +4 more
doaj +1 more source
Cerebrospinal fluid levels of extracellular heat shock protein 72: A potential biomarker for bacterial meningitis in children [PDF]
Extracellular heat shock protein 72 (Hsp72) is an endogenous danger signal and potential biomarker for critical illness in children. We hypothesized that elevated levels of extracellular Hsp72 in the cerebrospinal fluid (CSF) of children with suspected ...
Kernie, Steven G. +5 more
core +1 more source
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Haematological values in a healthy adult population in Yaoundé, Cameroon
Background: Haematological values derived from local populations are useful in laboratories to improve diagnoses for local patients. In Cameroon, these data are not yet available.
Martin E. Oloume +8 more
doaj +1 more source
Study of chronic oral toxicity of the aqueous extract of Seed of Peganum harmala L. A preliminary study on the effects of the aqueous extract on the blood of albino rats [PDF]
A preliminary study was conducted on the effect of aqueous extract of the seeds of the plant of Hermel (Peganum harmala L.), on the blood image in the white rats of both sexes.
Loay J. Rashan +6 more
doaj +1 more source
Longitudinal Intra- and Inter-individual variation in T-cell subsets of HIV-infected and uninfected men participating in the LA Multi-Center AIDS Cohort Study. [PDF]
To assess the intra-individual and inter-individuals biological variation and the effect of aging on lymphocyte T-cells subsets.We assessed lymphocyte phenotypes (CD3, CD4, and CD8 T-cells) in 89 HIV-1-infected and 88 uninfected white non-Hispanic men ...
Aziz, Najib +5 more
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