Results 71 to 80 of about 747,398 (307)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Increased Expression of Cell-Cell Signaling Genes by Stimulated Mononuclear Leukocytes in Patients with Previous Atherothrombotic Stroke A Whole Genome Expression Profile Study [PDF]

, 2009
Background/Aims: Inflammation plays an important role in atherosclerosis and stroke. Acute infections are recognized as trigger factors for ischemic stroke. Methods: In this whole genome expression profile study of 15 patients and 15 control subjects, we
Wiest, Tina, Horstmann, Solveig, Honold, Cornelius, Hergenhahn, Manfred, Mansmann, Ulrich, Wagner, Simone, Weninger, Annette, Pfleger, Karin, Grond-Ginsbach, Caspar, Hollstein, Monika, Grau, Armin J., Hummel, Manuela, Knyazev, Yuri   +12 more
core   +1 more source

Referências hematológicas para a jararaca de rabo branco (Bothrops leucurus) recém capturadas da natureza Hematological references for wild recently-caught white-tailed lancehead (Bothrops leucurus)

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2006
The hematological values for the specie Bothrops leucurus, recently captured from nature, were determined from blood samples of 29 snakes (11 males and 18 females).
K.F. Grego, J.A.S. Alves, L.C. Rameh de Albuquerque, W. Fernandes   +3 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Epstein–Barr Virus Infection Related to Low White Blood Cell Count in Cancer Patients Receiving Chemotherapy in Al-Najaf Governorate/Iraq

, 2020
Epstein-Barr virus (EBV) plays the most important role in various types of human cancers. Patients receiving chemotherapy have low white blood cell (WBC) counts that elevate the risk of infection and is the first public health priority in Iraq.
Heider Hemeed Abbas, Thikra Abdullah Mahmood, Saif Jabbar Yasir   +2 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

KIT mutation analysis in mast cell neoplasms: recommendations of the European competence network on mastocytosis [PDF]

, 2015
Although acquired mutations in KIT are commonly detected in various categories of mastocytosis, the methodologies applied to detect and quantify the mutant type and allele burden in cells and various tissues are poorly defined.
T. Haferlach, Reiter, A., Sperr, W. R., Akin, C, Valent, P., C. Akin, Garcia-Montero, A., G. Hoermann, Broesby-Olsen, S, Triggiani, M, Escribano, L, Hartmann, K.., Kluin-Nelemans, H. C., Cross, N.C.P., J. Gotlib, A. Reiter, Hermine, O., Akin, C., K. Sotlar, Haferlach, T, S. Broesby Olsen, Hoermann, G., TRIGGIANI, MASSIMO, P. Valent, A. Garcia Montero, Metcalfe, D. D., Sperr, W R, Broesby-Olsen, S., Gotlib, J, Kristensen, T. K., Arock, M, N. C. P. Cross, Schwaab, J., M. Arock, K. Hartmann, Schwaab, J, Metcalfe, D D, Escribano, L., O. Hermine, Kluin-Nelemans, H.C., Hermine, O, W. R. Sperr, J. Schwaab, Hoermann, G, Triggiani, M., Metcalfe, D.D., Cross, N C P, Horny, H.-P., Kluin-Nelemans, H C, Sotlar, K., D. D. Metcalfe, Sperr, W.R., Horny, H-P, Valent, P, Orfao, A., P. Dubreuil, Reiter, A, T. K. Kristensen, Orfao, A, Dubreuil, P., A. Orfao, Gotlib, J., L. Escribano, Sotlar, K, Kristensen, T.K., Hartmann, K., Cross, N. C. P., Haferlach, T., Dubreuil, P, Kielsgaard Kristensen, Thomas, Arock, M., Garcia-Montero, A, H. C. Kluin Nelemans, H. P. Horny, Hartmann, K   +74 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Association of Severity of Posttraumatic Stress Disorder With Inflammation: Using Total White Blood Cell Count as a Marker

Chronic Stress, 2019
Background Inflammation is known to be associated with posttraumatic stress disorder. It is not known if total white blood cell count, a routinely checked inflammatory marker, is associated with posttraumatic stress disorder symptom trajectories using ...
Farrukh M. Koraishy, Joanne Salas, Thomas C. Neylan, Beth E. Cohen, Paula P. Schnurr, Sean Clouston, Jeffrey F. Scherrer   +6 more
doaj   +1 more source