Results 71 to 80 of about 1,992,807 (367)

A Methodical Approach to Interpreting the Red Blood Cell Parameters of the Complete Blood Count

American Society for Clinical Laboratory Science, 2017
A methodical approach to interpreting the panel of complete blood count (CBC) results helps to ensure that spurious results are detected and corrected before results are reported and helps to ensure that no results are overlooked in a diagnostic analysis
K. Doig, Bei Zhang
semanticscholar   +1 more source

Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors – a biomarker analysis of the ALICE and ICON trials

Molecular Oncology, EarlyView.
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Elin Borgen, Cecilie Bendigtsen Schirmer, Bjørnar Gilje, Øystein Garred, Jon Lømo, Marius Stensland, Oddmund Nordgård, Ragnhild Sørum Falk, Randi R. Mathiesen, Hege G. Russnes, Jon Amund Kyte, Bjørn Naume   +13 more
wiley   +1 more source

Circulating tumor cells: advancing personalized therapy in small cell lung cancer patients

Molecular Oncology, EarlyView.
Small cell lung cancer (SCLC) is an aggressive form of lung cancer that spreads rapidly to secondary sites such as the brain and liver. Cancer cells circulating in the blood, “circulating tumor cells” (CTCs), have demonstrated prognostic value in SCLC, and evaluating biomarkers on CTCs could guide treatment decisions such as for PARP inhibitors ...
Prajwol Shrestha, Steven Kao, Veronica K. Cheung, Wendy A. Cooper, Nico van Zandwijk, John E. J. Rasko, Dannel Yeo   +6 more
wiley   +1 more source

Localization of Malaria Parasites and White Blood Cells in Thick Blood Smears [PDF]

arXiv, 2020
Effectively determining malaria parasitemia is a critical aspect in assisting clinicians to accurately determine the severity of the disease and provide quality treatment. Microscopy applied to thick smear blood smears is the de facto method for malaria parasitemia determination.
arxiv  

A comparative study of circulating tumor cell isolation and enumeration technologies in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells were spiked into donor blood to evaluate the recovery rates of the following circulating tumor cell (CTC) enrichment technologies: CellMag™, EasySep™, RosetteSep™, Parsortix® PR1, and Parsortix® Prototype systems. Each method's advantages and disadvantages are described.
Volga M Saini, Ezgi Oner, Mark P. Ward, Sinead Hurley, Brian David Henderson, Faye Lewis, Stephen P. Finn, Gerard J. Fitzmaurice, John J. O'Leary, Sharon O'Toole, Lorraine O'Driscoll, Kathy Gately   +11 more
wiley   +1 more source

Cell type specific DNA methylation in cord blood: A 450K-reference data set and cell count-based validation of estimated cell type composition

Epigenetics, 2016
Epigenome-wide association studies of prenatal exposure to different environmental factors are becoming increasingly common. These studies are usually performed in umbilical cord blood.
K. Gervin, C. Page, H. Aass, M. Jansen, H. Fjeldstad, B. K. Andreassen, L. Duijts, J. V. van Meurs, M. V. van Zelm, V. Jaddoe, H. Nordeng, G. Knudsen, P. Magnus, W. Nystad, A. Staff, J. Felix, R. Lyle   +16 more
semanticscholar   +1 more source

A fast semi-automatic method for classification and counting the number and types of blood cells in an image [PDF]

arXiv, 2020
A novel and fast semi-automatic method for segmentation, locating and counting blood cells in an image is proposed. In this method, thresholding is used to separate the nucleus from the other parts. We also use Hough transform for circles to locate the center of white cells. Locating and counting of red cells is performed using template matching.
arxiv  

KRAS and GNAS mutations in cell‐free DNA and in circulating epithelial cells in patients with intraductal papillary mucinous neoplasms—an observational pilot study

Molecular Oncology, EarlyView.
This study demonstrates that KRAS and GNAS mutations are more prevalent in patients with resected intraductal papillary mucinous neoplasms (IPMN) compared to those under clinical surveillance. GNAS mutations significantly differ between the two patient cohorts, indicating that their absence may serve as a potential biomarker to support conservative ...
Christine Nitschke, Marie Tölle, Philipp Walter, Kira Meißner, Mara Goetz, Jolanthe Kropidlowski, Andreas W. Berger, Jakob R. Izbicki, Felix Nickel, Thilo Hackert, Klaus Pantel, Harriet Wikman, Faik G. Uzunoglu   +12 more
wiley   +1 more source

White blood cell count is an independent predictor of outcomes after acute ischaemic stroke

European Journal of Neurology, 2014
In patients with ischaemic stroke, elevated white blood cell count (WBC) has been associated with stroke severity on admission and poor functional outcome. However, previous studies did not control for confounding factors. We hypothesized that higher WBC
J. Furlan, M. Vergouwen, J. Fang, F. Silver   +3 more
semanticscholar   +1 more source

TIMELY: Improving Labeling Consistency in Medical Imaging for Cell Type Classification [PDF]

arXiv, 2020
Diagnosing diseases such as leukemia or anemia requires reliable counts of blood cells. Hematologists usually label and count microscopy images of blood cells manually. In many cases, however, cells in different maturity states are difficult to distinguish, and in combination with image noise and subjectivity, humans are prone to make labeling mistakes.
arxiv