Results 1 to 10 of about 2,454,570 (173)

A Portrait of Cord Blood Units Distributed for Transplantation from Canadian Blood Services’ Cord Blood Bank: First Analysis

Current Oncology, 2022
Background: The Canadian Blood Services Cord Blood Bank (CBS CBB) was created to improve access to stem cell products for transplantation for patients across ethnic groups.
Gaganvir Parmar, Meagan Green, Karen Mostert, Tiffany Lawless, Nicholas Dibdin, Jason Weiss, Kathy Ganz, Tanya Petraszko, Matthew D. Seftel, David S. Allan   +9 more
doaj   +1 more source

The Effect of the COVID-19 Pandemic on Unrelated Allogeneic Hematopoietic Donor Collections and Safety

Current Oncology, 2023
Background and Objectives: The COVID-19 pandemic profoundly influenced unrelated donor (UD) allogeneic peripheral blood stem cell (PBSC) collections. Changes included efforts to minimize COVID-19 exposure to donors and cryopreservation of products.
Gaganvir Parmar, David S. Allan, Gail Morris, Nicholas Dibdin, Kathy Ganz, Karen Mostert, Kristjan Paulson, Tanya Petraszko, Nora Stevens, Matthew D. Seftel   +9 more
doaj   +1 more source

Rapid GMP-Compliant Expansion of SARS-CoV-2–Specific T Cells From Convalescent Donors for Use as an Allogeneic Cell Therapy for COVID-19

Frontiers in Immunology, 2021
COVID-19 disease caused by the SARS-CoV-2 virus is characterized by dysregulation of effector T cells and accumulation of exhausted T cells. T cell responses to viruses can be corrected by adoptive cellular therapy using donor-derived virus-specific T ...
Rachel S. Cooper, Alasdair R. Fraser, Linda Smith, Paul Burgoyne, Stuart N. Imlach, Lisa M. Jarvis, David M. Turner, Sharon Zahra, Marc L. Turner, John D. M. Campbell   +9 more
doaj   +1 more source

BCL2 Inhibition: A New Paradigm for the Treatment of AML and Beyond

HemaSphere, 2023
Altering the natural history of acute myeloid leukemia (AML) in unfit and older patients has proved a highly challenging hurdle, despite several decades of concerted clinical trial effort.
Andrew H. Wei, Andrew W. Roberts
doaj   +1 more source

NAb-seq: an accurate, rapid, and cost-effective method for antibody long-read sequencing in hybridoma cell lines and single B cells

mAbs, 2022
Despite their common use in research, monoclonal antibodies are currently not systematically sequenced. This can lead to issues with reproducibility and the occasional loss of antibodies with loss of cell lines. Hybridoma cell lines have been the primary
Hema Preethi Subas Satish, Kathleen Zeglinski, Rachel T. Uren, Stephen L. Nutt, Matthew E. Ritchie, Quentin Gouil, Ruth M. Kluck   +6 more
doaj   +1 more source

Persistence of CRISPR/Cas9 gene edited hematopoietic stem cells following transplantation: A systematic review and meta‐analysis of preclinical studies

Stem Cells Translational Medicine, 2021
Gene editing blood‐derived cells is an attractive approach to cure selected monogenic diseases but remains experimental. A systematic search of preclinical controlled studies is needed to determine the persistence of edited cells following reinfusion ...
Harinad B. Maganti, Adrian J. M. Bailey, Aidan M. Kirkham, Risa Shorr, Nicolas Pineault, David S. Allan   +5 more
doaj   +1 more source

The use of mesenchymal stromal cells in the treatment of coronavirus disease 2019

Journal of Translational Medicine, 2020
More than seven months into the coronavirus disease -19 (COVID-19) pandemic, infection from the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has led to over 21.2 million cases and resulted in over 760,000 deaths worldwide so far.
Maurice A. Canham, John D. M. Campbell, Joanne C. Mountford   +2 more
doaj   +1 more source

Sustained immunotolerance in multiple sclerosis after stem cell transplant

Annals of Clinical and Translational Neurology, 2022
Objective Autologous haematopoietic stem cell transplantation (AHSCT) has the potential to induce sustained periods of disease remission in multiple sclerosis (MS), which is an inflammatory disease of the central nervous system (CNS) characterised by ...
Malini Visweswaran, Kevin Hendrawan, Jennifer C. Massey, Melissa L. Khoo, Carole D. Ford, John J. Zaunders, Barbara Withers, Ian J. Sutton, David D. F. Ma, John J. Moore   +9 more
doaj   +1 more source

New-Generation Ektacytometry Study of Red Blood Cells in Different Hemoglobinopathies and Thalassemia

Thalassemia Reports, 2023
Next-generation ektacytometry provided by the osmoscan module of the Laser Optical Rotational Red Cell Analyser (LoRRca) MaxSis is, so far, one of the best complementary diagnostic tools for congenital rare anaemias due to red blood cell defects. Osmotic
Elena Krishnevskaya, Marta Molero, Águeda Ancochea, Ines Hernández, Joan-Lluis Vives-Corrons   +4 more
doaj   +1 more source

DARS2 overexpression is associated with PET/CT metabolic parameters and affects glycolytic activity in lung adenocarcinoma

Journal of Translational Medicine, 2023
Background This study investigated the correlation between the expression of DARS2 and metabolic parameters of 18F-FDG PET/CT, and explored the potential mechanisms of DARS2 affecting the proliferation and glycolysis of lung adenocarcinoma (LUAD) cells ...
Xu-Sheng Liu, Ling-Ling Yuan, Yan Gao, Xing Ming, Yao-Hua Zhang, Yu Zhang, Zi-Yue Liu, Yi Yang, Zhi-Jun Pei   +8 more
doaj   +1 more source