Results 81 to 90 of about 17,492,293 (382)

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Deformability of Tumor Cells versus Blood Cells

Scientific Reports, 2015
The potential for circulating tumor cells (CTCs) to elucidate the process of cancer metastasis and inform clinical decision-making has made their isolation of great importance.
Josephine Shaw Bagnall, Sangwon Byun, Shahinoor Begum, D. Miyamoto, Vivian C. Hecht, S. Maheswaran, Shannon L. Stott, M. Toner, R. Hynes, S. Manalis   +9 more
semanticscholar   +1 more source

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

Quality of the blood sampled from surgical drainage after total hip arthroplasty [PDF]

, 2008
Several methods have been found to be successful in reducing the need for allogeneic transfusion among the patients undergoing total hip replacement.
Buković, Damir, Buković, Nevia, Radaković, Branko, Tripković, Branko, Šakić, Katarina, Šakić, Šime   +5 more
core  

MicroRNAs as Haematopoiesis Regulators

Advances in Hematology, 2013
The production of different types of blood cells including their formation, development, and differentiation is collectively known as haematopoiesis.
Ram Babu Undi, Ravinder Kandi, Ravi Kumar Gutti   +2 more
doaj   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Predominance of weakly cytotoxic, T-betLowEomesNeg CD8+ T-cells in human gastrointestinal mucosa: implications for HIV infection. [PDF]

, 2017
The gastrointestinal mucosa is an important site of HIV acquisition, viral replication, and pathogenesis. Immune cells in mucosal tissues frequently differ in phenotype and function from their non-mucosal counterparts.
Critchfield, JW, Deeks, SG, Ganesh, A, Hecht, FM, Hunt, PW, Kiniry, BE, Shacklett, BL, Somsouk, M   +7 more
core   +1 more source

EBV T-cell immunotherapy generated by peptide selection has enhanced effector functionality compared to LCL stimulation

Frontiers in Immunology
Adoptive immunotherapy with Epstein–Barr virus (EBV)-specific T cells is an effective treatment for relapsed or refractory EBV-induced post-transplant lymphoproliferative disorders (PTLD) with overall survival rates of up to 69%.
Rachel S. Cooper, Rachel S. Cooper, Catherine Sutherland, Linda M. Smith, Graeme Cowan, Mark Barnett, Donna Mitchell, Colin McLean, Stuart Imlach, Alan Hayes, Sharon Zahra, Champa Manchanayake, Mark A. Vickers, Mark A. Vickers, Gerry Graham, Neil W. A. McGowan, Marc L. Turner, John D. M. Campbell, John D. M. Campbell, Alasdair R. Fraser, Alasdair R. Fraser   +20 more
doaj   +1 more source

Optimal large‐scale CD34+ enrichment from a leukapheresis collection using the clinimacs prodigy platform

Clinical Case Reports, 2020
Optimization of Hematology Patient's treatment: It is possible to obtain a 100% CD34+ recovery after CD34+ selection using the CliniMACS Prodigy.
Oscar M. Pello, Diego Lanzarot, Mercedes Colorado, Cristina Amunarriz, Andrés Insunza, Lorena Álvarez‐Rodríguez, María Díez de Velasco, Natividad Sainz‐Sainz, José Luis Arroyo   +8 more
doaj   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source