Results 301 to 310 of about 484,763 (358)
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The Lancet, 2000
Under normal circumstances, the coagulation system is balanced in favour of anticoagulation. Thrombin is the key effector enzyme of the clotting cascade. Antagonists of vitamin K inhibit a vitamin-K-dependent post-translational modification of several coagulation proteins, which is required for these proteins to attain a phospholipid-binding ...
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Under normal circumstances, the coagulation system is balanced in favour of anticoagulation. Thrombin is the key effector enzyme of the clotting cascade. Antagonists of vitamin K inhibit a vitamin-K-dependent post-translational modification of several coagulation proteins, which is required for these proteins to attain a phospholipid-binding ...
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Best Practice & Research Clinical Obstetrics & Gynaecology, 2003
Blood coagulation can be initiated by two pathways: the extrinsic pathway, which is triggered by release of tissue factor from the site of injury, and the intrinsic system, which is stimulated by contact with a negatively charged surface. Following initial triggering, a series of serine proteases are sequentially activated, culminating in the formation
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Blood coagulation can be initiated by two pathways: the extrinsic pathway, which is triggered by release of tissue factor from the site of injury, and the intrinsic system, which is stimulated by contact with a negatively charged surface. Following initial triggering, a series of serine proteases are sequentially activated, culminating in the formation
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American Journal of Physiology-Legacy Content, 1962
Blood coagulation systems in cyclostome, elasmobranch, and teleost fish were studied and compared. The plasma of all these fish contained a fibrinogen molecule, capable of being clotted by human thrombin, and a prothrombin molecule, capable of being converted into thrombin which could hydrolyze p-tosyl l-arginine methyl ester. The prothrombin activity
Russell F, Doolittle +1 more
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Blood coagulation systems in cyclostome, elasmobranch, and teleost fish were studied and compared. The plasma of all these fish contained a fibrinogen molecule, capable of being clotted by human thrombin, and a prothrombin molecule, capable of being converted into thrombin which could hydrolyze p-tosyl l-arginine methyl ester. The prothrombin activity
Russell F, Doolittle +1 more
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Blood Coagulation and Fibrinolysis
Angewandte Chemie International Edition in English, 1971AbstractAs a result of advances in protein chemistry it is now widely accepted that blood coagulation proceeds via a series of reaction steps of the nature of enzyme‐substrate reactions catalyzed by phospholipids. This also applies to the compensatory process of fibrinolysis.
N, Heimburger, H, Trobisch
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Blood Coagulation and Coagulation Tests
Medical Clinics of North America, 1984The hemostatic mechanism has evolved to provide efficient protection from traumatic blood loss and yet maintain the blood in a fluid state in the circulation as a whole. Recent advances in biochemistry have provided both detailed understanding of hemostasis and clinically useful coagulation assays to exploit this understanding.
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Biorheology, 1996
There have been a number of investigations on coagulation reactions of blood as well as on coagulation factors including fibrinogen and thrombin. With the progress of clotting, the viscosity and rigidity of blood increase, facts related to the clot structure of fibrin.
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There have been a number of investigations on coagulation reactions of blood as well as on coagulation factors including fibrinogen and thrombin. With the progress of clotting, the viscosity and rigidity of blood increase, facts related to the clot structure of fibrin.
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Blood Cells, Molecules, and Diseases, 2006
Our research aims to provide quantitatively transparent, biologically realistic descriptions of the processes involved in hemostasis which will permit predictions of the behavior of the coagulation system in normal and pathologic states. We use four models of coagulation: (1) numerical approximations of the tissue factor (Tf) pathway of thrombin ...
Kenneth G, Mann +3 more
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Our research aims to provide quantitatively transparent, biologically realistic descriptions of the processes involved in hemostasis which will permit predictions of the behavior of the coagulation system in normal and pathologic states. We use four models of coagulation: (1) numerical approximations of the tissue factor (Tf) pathway of thrombin ...
Kenneth G, Mann +3 more
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The kinetics of blood coagulation
The Bulletin of Mathematical Biophysics, 1948The kinetics of the blood coagulation system have been formulated and an expression obtained for the “prothrombin time” in terms of the concentrations of the components of the system. A linear plot of data obtained from plasma dilution curves gives the values of the parameters of the system, and yields a mathematical method of comparing relative ...
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Blood coagulation in glomerulonephritis
International Urology and Nephrology, 1986Different parameters of coagulation were studied in 71 patients with glomerulonephritis. In comparison with normal subjects they had lower platelet counts, lower adhesion index and decreased aggregation, decreased partial thromboplastin time (46.4 per cent of patients), increased reptilase time (47.8 per cent) and other disorders. Plasma fibrin monomer
N, Belovezhdov, R, Robeva, V, Genova
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American Journal of Obstetrics and Gynecology, 1987
Blood coagulation consists of several interrelated reactions involving platelets and blood vessels, the classical cascade, and the fibrinolytic system. There is a complex of inhibiting influences on each of these schemes, and there are interrelationships among these inhibitory influences.
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Blood coagulation consists of several interrelated reactions involving platelets and blood vessels, the classical cascade, and the fibrinolytic system. There is a complex of inhibiting influences on each of these schemes, and there are interrelationships among these inhibitory influences.
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