Results 111 to 120 of about 123,153 (305)
the pharmacological management of genetically determined coagulation disorders
This thesis explores the pharmacological management of inherited blood coagulation disorders, which include both hemorrhagic conditions like hemophilia A and B and von Willebrand disease, as well as thrombophilic disorders such as Factor V Leiden ...
Yokoshima, Kotone
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CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction
Advanced Science, EarlyView.CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma +12 more
wiley +1 more source
Community Counts: The HTC Population Profile - March 2023
The HTC Population Profile is a set of twelve data items collected on patients with bleeding disorders or venous thromboembolism. Updated data tables describing patient characteristics from the HTC Population Profile through March 31st, 2023 are ...
core
Advanced Science, EarlyView.Hollow Co3O4/TiO2 heterojunctions are engineered for high‐throughput laser desorption/ionization mass spectrometry. The built‐in electric field drives efficient charge separation and photothermal conversion, while the hierarchical mesoporous network enables robust salt and protein tolerance.
Junyu Chen +8 more
wiley +1 more source
Mathematical Modeling of Blood Coagulation
, 2016 Blood coagulation is a series of biochemical reactions that take place to form a blood clot. Abnormalities in coagulation, such as under-clotting or over- clotting, can lead to significant blood loss, cardiac arrest, damage to vital organs, or even death.
Perdomo, Joana L
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Skin autoimmunity and blood coagulation
, 2010 Evidence exists that the immune and coagulation systems are simultaneously activated in some systemic autoimmune disorders. Although proinflammatory mediators induce tissue factor (TF) expression, the main initiator of blood coagulation,activated ...
A. Tedeschi +4 more
core +1 more source
A Plug‐and‐Play Platform for Customizing Multivalent Degraders and Degrader‐Drug Conjugates
Advanced Science, EarlyView.Membrane proteins remain challenging targets for conventional TPD approaches. Here, the authors develop UPTAB, a modular platform leveraging ultrahigh‐affinity orthogonal Im/CL protein pairs for lysosomal degradation of membrane proteins. Mono‐targeted (Type‐I), dual‐targeted (Type‐II), and tri‐targeted (Type‐III) UPTABs enable simultaneous degradation
Mengqing Zhao +7 more
wiley +1 more source
Терапевтический архив, 2015 Aim. To study blood coagulation and microcirculatory disorders as a possible cause of transient dysfunctions of organs (the kidney, liver, heart, lung, etc.) in patients with ixodid tick-borne borreliosis caused by Borrelia miyamotoi (Bmt).
A E Platonov +6 more
doaj
Community Counts : The HTC Population Profile [through March 31st, 2017]
The HTC Population Profile is a set of twelve data items collected on patients with bleeding disorders or venous thromboembolism. Updated data tables describing patient characteristics from the HTC Population Profile through March 31st, 2017 are ...
core
Acquired coagulation disorders
Acquired disorders of haemostasis are a varied group of disorders with often complex and overlapping aetiologies. This chapter will review the aetiology, investigation and management of these disorders.
Thachil, Jecko, Collins, Peter W.
core +1 more source