Results 121 to 130 of about 3,484,780 (294)

Hemofilia no estado de Santa Catarina: estudo clínico [PDF]

open access: yes, 2006
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde.
Hoepers, Andréa Thives de Carvalho
core  

TRIM28‐Derived Peptide Exerts Anti‐Tumor Roles by Stabilizing Tumor Suppressive BRD7 Protein in Multiple Cancers

open access: yesAdvanced Science, EarlyView.
An α‐helical peptide, TAB12, designed to mimic the TRIM28 binding interface, competitively disrupts the TRIM28‐BRD7 interaction, thereby blocking ubiquitin‐mediated degradation of the tumor suppressor BRD7. This stabilization unleashes potent anti‐tumor effects across multiple tumor types with a favorable safety profile, offering a feasible strategy ...
Qingqing Wei   +10 more
wiley   +1 more source

Chimeric IL‐6/4R‐LL37 Engineered Macrophages Achieve Synchronized Inflammation Control and Antimicrobial Defence in Sepsis

open access: yesAdvanced Science, EarlyView.
Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie   +10 more
wiley   +1 more source

Community Counts: The HTC Population Profile - March 2023

open access: yes
The HTC Population Profile is a set of twelve data items collected on patients with bleeding disorders or venous thromboembolism. Updated data tables describing patient characteristics from the HTC Population Profile through March 31st, 2023 are ...

core  

Complications and management of coagulation disorders in leukemia patients

open access: yes, 2017
Deepesh Lad, Arihant Jain, Subhash Varma Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India Abstract: Patients with leukemia are predisposed to various coagulation abnormalities ...
Jain A, Lad DP, Varma S
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Bioadhesive‐Integrated 3D‐Printed Multilayer Scaffolds Secure a Mechanically‐Stable Osteoimmune Niche for Enhanced Bone Augmentation

open access: yesAdvanced Science, EarlyView.
A 3D‑printed multilayer adhesive scaffold, firmly anchored to bone defects by simple finger pressing, suppresses micromotion and secures mechanical stability of the osteogenic niche. This stabilization likely contributes to the enhanced bone augmentation by fostering a pro‑regenerative mechano‐immune profile—characterized by M2‑like macrophage ...
Delu Zhao   +7 more
wiley   +1 more source

Electronic Chip‐Mimetic Medical Implants for Controllable Sonothermal Treatments

open access: yesAdvanced Science, EarlyView.
Inspired by the thermal effect of working electronic chips, which consist of various heterostructures, an sonothermal‐responsive platform has been developed through constructing metal‐semiconductor interface on implants. Biofilm infection and deep vein thrombosis can be successfully treated by controllable ultrasound treatments.
Zhengdong Zhang   +10 more
wiley   +1 more source

the pharmacological management of genetically determined coagulation disorders

open access: yes
This thesis explores the pharmacological management of inherited blood coagulation disorders, which include both hemorrhagic conditions like hemophilia A and B and von Willebrand disease, as well as thrombophilic disorders such as Factor V Leiden ...
Yokoshima, Kotone
core  

One‐Step Immobilized Phage Depolymerase Coatings for Catheter‐Related Bloodstream Infections

open access: yesAdvanced Science, EarlyView.
Catheter‐related bloodstream infections (CRBSI) caused by drug‐resistant Gram‐negative bacteria remain a major clinical challenge. Here, a polydopamine‐assisted depolymerase coating degrades bacterial capsules and restores serum‐mediated killing, effectively suppressing biofilms and reducing bacterial burden in vitro, ex vivo, and in vivo, presenting a
Lingkai Dong   +11 more
wiley   +1 more source

Assessment of the Dental Students Awareness about Bleeding Disorders in Buraidah and Riyadh city, Saudi Arabia

open access: yesAdvances in Human Biology, 2016
Aim: To assess dental students (6th year and Interns) knowledge and attitude regarding management of bleeding disorders in Buraidah and Riyadh City. Materials and method: A cross sectional survey was conducted among dental students enrolled in 6th year ...
Shrudha Potdar   +4 more
doaj  

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