Results 81 to 90 of about 123,153 (305)

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

Tropomyosin 1 Promotes Platelet Adhesion and Clot Contraction Separate from Its Roles in Developmental Hematopoiesis

Advanced Science, EarlyView.
ABSTRACT Genome‐wide association studies (GWAS) link the Tropomyosin 1 (Tpm1) locus to quantitative blood trait variation, but related mechanisms are unclear. Tpm1 encodes an actin‐binding protein that regulates actin filament diversity, cell adhesion, signaling, and actomyosin contractility.
Po‐Lun Kung, Victor Tsao, Alina D Peshkova, Oscar A. Marcos‐Contreras, Kim Ha, Brian M Dulmovits, Nkemdilim Okoli, Anvi Sinha, Gennadiy Fonar, Rong Qiu, Rolf D Bates, Janelle Yeboah, Carson Shalaby, Tyler Truex, Soomin Jeong, Edna C Hardeman, Peter W Gunning, Vladimir R Muzykantov, Jacob W Myerson, Christopher S Thom   +19 more
wiley   +1 more source

Precision infusion of cryoprecipitate in rare bleeding disorders

Zhongguo shuxue zazhi
The coagulation factors in cryoprecipitate are mainly coagulation factor Ⅷ, fibrinogen, von Willebrand factor (VWF), and coagulation factor ⅩⅢ. This article provides different treatment dosages and plans for different patients with rare coagulation ...
SUN Changkui, WANG Tiantian, WANG Jie, FANG Yunhai   +3 more
doaj   +1 more source

DIAGNOSTICS OF HEMOSTASIS DISORDERS IN INFANTS

Акушерство, гинекология и репродукция, 2016
This clinical lecture is dedicated to the diagnostic approaches of blood coagulation disorders in newborns. The work presents a clinical substantiation of different diagnostic methods of hemostasis disorders with description of routine standard methods ...
A. L. Mishchenko, N. M. Khamani, N. S. Stuleva   +2 more
doaj   +1 more source

Full‐Body AI Agent: A Perspective on Multi‐Scale Collaborative AI for Systemic Biology and Precision Medicine

Advanced Science, EarlyView.
We propose the Full‐Body AI Agent, a multi‐scale collaborative framework with 7 biological‐layer agents. It unifies multi‐omics/clinical data via standardized protocols, enabling phenotype‐guided closed‐loop reasoning, quantitative evaluation, and LLM safeguards, with promising applications in tumor metastasis modeling and precision drug development ...
Aoqi Wang, Jiajia Liu, Jianguo Wen, Yangyang Luo, Zhiwei Fan, Liren Yang, Xi Hu, Ruihan Luo, Yankai Yu, Sophia Li, Weiling Zhao, Xiaobo Zhou   +11 more
wiley   +1 more source

FIBRINOLYSIS: MODERN VIEW, PATHOLOGY, DIAGNOSTICS

Байкальский медицинский журнал
Relevance. Fibrinolysis is an important and integral part of the hemostasis system. Acting in parallel and together, the blood coagulation and fibrinolysis systems protect the body from excessive thrombus formation and vascular occlusion, on the one hand,
Lyudmila O. Gutsol, Irina E. Egorova, Igor Zh. Seminsky, Evgenia V. Guzovskaiia, Svetlana N. Serebrennikova, Lyudmila A. Dmitrieva   +5 more
doaj   +1 more source

Severe Postpartum Coagulopathy Without Haemorrhage: A Case Report

Acta Médica Portuguesa, 2018
Postpartum haemorrhage is an important health issue worldwide, and it can be caused by uterine atony, retained placental tissue, trauma or coagulation disorders. Although coagulopathy represents a rare cause, it is a significant contributor to postpartum
Muriel Lérias-Cambeiro, Anabela Rodrigues, Inês Taborda, Filipa Lança   +3 more
doaj   +1 more source

Co-expression of Factor VIII with anti-FVIII Camelid antibody ligands: Effect on expression levels of bio-therapeutic FVIII [PDF]

, 2015
Production of recombinant FVIII, the protein that is missing or dysfunctional in haemophilia A patients, is highly inefficient compared to other recombinant clotting factors such as FIX.
Tolley, Caroline
core  

Thyroid-associated autoimmune coagulation disorders.

, 2010
Abnormalities of blood coagulation are not rarely observed in patients with thyroid dysfunctions and may range from subclinical laboratory abnormalities to clinically significant hemorrhagic or thrombotic complications.
Giuseppe Lippi, Pier Paolo Vescovi, Manzato F, Massimo Franchini, Franco Manzato, LIPPI, Giuseppe, Vescovi P.P., Franchini M   +7 more
core   +1 more source

Methylglyoxal Accumulation is Associated with Brain Inflammation after Myocardial Infarction with Sex and Regional Differences

Advanced Science, EarlyView.
This study identifies that methylglyoxal may play an important role in heart‐brain interactions after myocardial infarction. Myocardial infarction leads to increased levels of methylglyoxal‐derived advanced glycation end‐products (MG‐H1) in the brain of mice, which is associated with loss of blood‐brain barrier integrity and neuroinflammation ...
Ramis Ileri, Xixi Guo, Erik J. Suuronen
wiley   +1 more source