Results 71 to 80 of about 3,484,780 (294)

Mr BMT Achieves Systemic Macrophage Replacement With Preservation of Tissue Homeostasis

Advanced Science, EarlyView.
Microglia replacement by bone marrow transplantation (Mr BMT) enables systemic replacement of tissue‐resident macrophages. Despite persistent macrophage and tissue remodeling across multiple organs, core biological functions and innate immune responses remain preserved, supporting long‐term maintenance of organismal homeostasis and the therapeutic ...
Yufei Xu, Miaozhan Zou, Yunshang Bai, Yang He, Zhihao Jin, Baozhi Yang, Jinjin Du, Pei Ouyang, Yuanyuan Cai, Yuheng Zhang, Bingying Du, Chengcheng Ge, Jian‐an Gong, Xiaoyu Li, Yuanyi Zheng, Jing Ding, Bo Peng, Yanxia Rao   +17 more
wiley   +1 more source

Clinical Profile and Outcomes of Malabar Pit Viper (Trimeresurus malabaricus) Envenomation: A Retrospective Observational Study from Kerala, Southern India [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Kerala reports a high incidence of snakebites, with about 37 venomous species. Besides the “Big 4” (Cobra, Krait, Russell’s Viper, and Saw-scaled Viper), the Malabar Pit Viper (MPV) is also notable, especially in the Western Ghats.
Devapriya Rejeev, Sreelakshmi Mohanachandran, Aneesh Basheer   +2 more
doaj   +1 more source

Heat shock inhibits lipopolysaccharide-induced tissue factor activity in human whole blood [PDF]

, 2007
Background During gram-negative sepsis, lipopolysaccharide (LPS) induces tissue factor expression on monocytes. The resulting disseminated intravascular coagulation leads to tissue ischemia and worsens the prognosis of septic patients.
Thielmann, Matthias, Christoph Sucker, Zacharowski, Kai, Hartmann, Matthias, Kai Zacharowski, Matthias Thielmann, Sucker, Christoph, Sucker Christoph, Thielmann Matthias, Matthias Hartmann, Zacharowski Kai, Hartmann Matthias   +11 more
core   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source

Optimization of B Cell Responses in Human Immune System Mice Through Organoid Based Screening

Advanced Science, EarlyView.
Human immune system (HIS) mice show limited B cell responses to immunization. Using HIS mouse spleen organoids, this study identifies cytokine combinations and innate immune signals that drive human B cell expansion, differentiation, and class‐switch. Applying these signals in vivo through temporal separation enables antigen‐specific IgG responses and ...
Haiqiao Sun, He Li, Xu Zhu, Zijian Zhang, Deshan Ren, Shuai Ding, Yan Li   +6 more
wiley   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

Changes in Blood Coagulation Parameters and Platelet Indices in Pregnancies with Gestational Hypertension and Preeclampsia

Journal of Interdisciplinary Medicine
Hypertensive disorders of pregnancy impact approximately 10% of pregnancies worldwide. During pregnancy, there are changes in the expression of coagulation and fibrinolytic proteins that promote clot formation. While a normal pregnancy is associated with
Corduneanu Alina-Georgiana, Păvăleanu Ioana, Gerculy Renáta, Căpîlna Mihai Emil   +3 more
doaj   +1 more source

Trauma-induced coagulopathy in pediatric patients: an evidence-based approach [PDF]

Revista do Colégio Brasileiro de Cirurgiões
Trauma is the leading pediatric public health problem worldwide. Immaturity of the hemostatic system in children increases the risk of Trauma-Induced Coagulopathy (TIC). Therefore, based on a literature review, a clinical protocol was developed.
LEILA COSTA VOLPON, RAÍSSA CORREIA RAFAEL, ANA PAULA DE CARVALHO PANZERI CARLOTTI   +2 more
doaj   +4 more sources

Thermochemical Micro‐Explosion for Prompt Thrombolysis via Proximal Injection of Liquid Alkali Metal

Advanced Science, EarlyView.
We report a micro‐explosive thermochemical thrombolysis (METCT) therapy via injectable liquid alkali metal encapsulated in dimethyl silicone (LAM@oil). METCT enables prompt and safe vascular recanalization within 90 s. Critically, the LAM@oil system demonstrates significantly higher thrombolytic efficacy compared to clinically available thrombolytic ...
Xin Liao, Yi Hou, Jie Zhang, Bo Wang, Minghui Guo, Hua Qu, Wei Rao, Jing Liu   +7 more
wiley   +1 more source