IntroductionTo perform Calibrated Automated Thrombography (CAT), the use of reduced plasma volumes (referred to as “MidiCAT”) makes it possible to more efficiently use limited volumes of valuable biobanked plasma samples and decreases expenses for ...
Sebastien Charles+9 more
doaj +1 more source
The Organophosphate Paraoxon and Its Antidote Obidoxime Inhibit Thrombin Activity and Affect Coagulation In Vitro. [PDF]
Organophosphates (OPs) are potentially able to affect serine proteases by reacting with their active site. The potential effects of OPs on coagulation factors such as thrombin and on coagulation tests have been only partially characterized and potential ...
Valery Golderman+8 more
doaj +1 more source
Individualized Management of Coagulopathy in Patients with End-Stage Liver Disease
Over the last decades, individualized approaches and a better understanding of coagulopathy complexity in end-stage liver disease (ESLD) patients has evolved.
Tina Tomić Mahečić+8 more
doaj +1 more source
Microrheology and structural quantification of hypercoagulable clots [PDF]
We propose a combination of microrheological and structural characterizations of fibrin networks to study blood hypercoagulability. Fibrin is the central element of coagulation as its polymerization creates the network of fibers in which platelets and red blood cells are included.
arxiv
Platelet aggregation impacts thrombin generation assessed by calibrated automated thrombography
A calibrated automated thrombogram (CAT) is performed usually with human platelet-free plasma (PFP) but may be more relevant with platelet-rich plasma (PRP). In this case, platelets are not stimulated by subendothelial molecules like collagen.
Mélusine Didelot+5 more
doaj +1 more source
Comparison of standard coagulation testing with thromboelastometry tests in cardiac surgery [PDF]
Introduction: According to the several evidences, using thromboelastometry as a point of care test can be effective in reduction in blood loss and transfusion requirements in cardiac surgeries.
Elham Khalaf- Adeli+3 more
doaj +1 more source
Viscoelastic Tests in the Evaluation of Haemostasis Disturbances in SARS-CoV2 Infection
COVID-19 associated coagulopathy is a dysfunction of severe SARS-CoV-2 infection, characterized by significantly increased fibrinogen, D-dimer and C reactive protein and normal to near-normal prothrombin time, activated partial thromboplastin time and ...
Anabela Rodrigues+4 more
doaj +1 more source
Interference of Blood Cell Lysis on Routine Coagulation Testing
Abstract Context.—Preanalytical factors influencing the reliability of laboratory testing are commonplace. It is traditionally accepted that hemolytic samples are unsuitable for coagulation assays because of the release of hemoglobin, intracellular components, and thromboplastic substances from damaged blood cells ...
LIPPI, Giuseppe+3 more
openaire +5 more sources
Classical and Point-of-Care tests in severe hemorrhage management
Hemorrhage is defined as an acute loss of blood from the cardiovascular system. The hemostatic cascade (comprising the vasculature, coagulation factors, the fibrinolytic and the platelet systems) is the physiological mechanism meant to control this ...
Paolo Simioni
doaj +1 more source
Influence of Blood Lipids on Global Coagulation Test Results
High levels of blood lipids have been associated with high levels of coagulation factors. We investigated whether blood lipids influence the results of global coagulation tests, including prothrombin time (PT), activated partial thromboplastin time (aPTT), and thrombin generation assay (TGA).PT, aPTT, and TGA, along with procoagulant and anticoagulant ...
Jung-Ah Kim+3 more
openaire +3 more sources