Frontiers in Physiology, 2017 Background: The neonatal hemostatic system exhibits a fragile balance featuring lower levels of clotting factors as well as inhibitors. Neonatal platelets show in-vitro hypoaggregability, but neonates exhibit well-functioning primary and secondary ...
Axel Schlagenhauf +6 more
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It Is Written in the Clot: Coagulation Assessment in Severe Burn Injury
European Burn JournalBackground: Coagulopathy in severe burn injury is associated with complications and mortality. Methods: We compared 3 tests (EXTEM, INTEM, FIBTEM) of rotational thromboelastometry (ROTEM), a viscoelastic coagulation assay (VCA), with conventional ...
Eirini Nikolaidou +7 more
doaj +1 more source
Platelet aggregation impacts thrombin generation assessed by calibrated automated thrombography
Platelets, 2018 A calibrated automated thrombogram (CAT) is performed usually with human platelet-free plasma (PFP) but may be more relevant with platelet-rich plasma (PRP). In this case, platelets are not stimulated by subendothelial molecules like collagen.
Mélusine Didelot +5 more
doaj +1 more source
Individualized Management of Coagulopathy in Patients with End-Stage Liver Disease
Diagnostics, 2022 Over the last decades, individualized approaches and a better understanding of coagulopathy complexity in end-stage liver disease (ESLD) patients has evolved.
Tina Tomić Mahečić +8 more
doaj +1 more source
The Organophosphate Paraoxon and Its Antidote Obidoxime Inhibit Thrombin Activity and Affect Coagulation In Vitro. [PDF]
PLoS ONE, 2016 Organophosphates (OPs) are potentially able to affect serine proteases by reacting with their active site. The potential effects of OPs on coagulation factors such as thrombin and on coagulation tests have been only partially characterized and potential ...
Valery Golderman +8 more
doaj +1 more source
Health technology assessment of pathogen reduction technologies applied to plasma for clinical use [PDF]
, 2016 Although existing clinical evidence shows that the transfusion of blood components is becoming increasingly safe, the risk of transmission of known and unknown pathogens, new pathogens or re-emerging pathogens still persists.
Berrino, Alexandra +18 more
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Early and individualized goal-directed therapy for trauma-induced coagulopathy
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2012 Severe trauma-related bleeding is associated with high mortality. Standard coagulation tests provide limited information on the underlying coagulation disorder.
Schöchl Herbert +4 more
doaj +1 more source
Comparison of standard coagulation testing with thromboelastometry tests in cardiac surgery [PDF]
Journal of Cardiovascular and Thoracic Research, 2019 Introduction: According to the several evidences, using thromboelastometry as a point of care test can be effective in reduction in blood loss and transfusion requirements in cardiac surgeries.
Elham Khalaf- Adeli +3 more
doaj +1 more source
Viscoelastic Tests in the Evaluation of Haemostasis Disturbances in SARS-CoV2 Infection
Acta Médica Portuguesa, 2021 COVID-19 associated coagulopathy is a dysfunction of severe SARS-CoV-2 infection, characterized by significantly increased fibrinogen, D-dimer and C reactive protein and normal to near-normal prothrombin time, activated partial thromboplastin time and ...
Anabela Rodrigues +4 more
doaj +1 more source
Effects on coagulation of balanced (130/0.42) and non-balanced (130/0.4) hydroxyethyl starch or gelatin compared with balanced Ringer's solution: an in vitro study using two different viscoelastic coagulation tests ROTEM™ and SONOCLOT™† [PDF]
, 2017 Background Hydroxyethyl starch (HES) solutions compromise blood coagulation. Low molecular weight, low-substituted HES products, and electrolyte-balanced solutions might reduce this effect.
Casutt, M. +4 more
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