Results 121 to 130 of about 234,142 (282)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Characterization of filter membranes with application to red blood cell removal

, 2023
Removing red blood cells (RBCs) from blood to general RBC poor plasma is a common practice during blood tests, which improves the accuracy of biomarker detection in plasma.
Wu, Zhongnan
core  

Pharmacokinetics and outcome of tazobactam/piperacillin in Japanese patients undergoing low-flow continuous renal replacement therapy: dosage considerations

Clinical Pharmacology: Advances and Applications, 2017
Hanako Kohama,1 Takeshi Ide,1 Kazuro Ikawa,2 Norifumi Morikawa,2 Shinichi Nishi1 1Division of Intensive Care Unit, Hyogo College of Medicine, Nishinomiya, 2Department of Clinical Pharmacotherapy, Hiroshima University, Hiroshima, Japan Background ...
Kohama H, Ide T, Ikawa K, Morikawa N, Nishi S   +4 more
doaj  

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

The impact and deformation of press-fit metal acetabular components

, 2012
PhDEarly failure of some metal-on-metal (MoM) hip implants are extensively reported but not fully explained. These arthroplasties commonly utilise large-diameter, thin-walled acetabular cups that have the advantage of minimal removal of acetabular bone ...
Hothi, Hardip Singh
core  

K+ transport in red blood cells from human umbilical cord

, 2001
The current study was designed to characterise K+ transport in human fetal red blood cells, containing mainly haemoglobin F (HbF, and termed HbF cells), isolated from umbilical cords following normal parturition.
Gibson, John S., Ellory, J.Clive, Muzyamba, Morris C., J.Clive Ellory, Paul F. Speake, Luckas, Murray C.M., Ellory, J. Clive, Fattima Husain, John S. Gibson, Husain, Fattima, Speake, Paul F., Luckas, Murray C M, Morris C. Muzyamba, Murray C.M. Luckas   +13 more
core   +1 more source

APPARENT REMOVAL OF GRAFT‐VERSUS‐LEUKAEMIA EFFECT BY THE USE OF LEUCOCYTE‐POOR BLOOD COMPONENTS IN PATIENTS WITH ACUTE MYELOBLASTIC LEUKAEMIA [PDF]

British Journal of Haematology, 1989
J, Tucker, M F, Murphy, W M, Gregory, J, Lim, A Z, Rohatiner, A H, Waters, T A, Lister   +6 more
openaire   +2 more sources

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Application of Blood Purification to Non-Renal Organ Failure

, 2005
The application of artificial organs to the task of blood purification in the setting of non-renal organ failure simultaneously presents important challenges and opportunities.
J.A. Kellum, R. Venkataraman
core   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source