Results 111 to 120 of about 234,142 (282)

Efeitos agudos e crônicos do treinamento de futebol recreacional sobre indicadores fisiológicos, neuromusculares e bioquímicos em mulheres não treinadas [PDF]

, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Desportos, Programa de Pós-Graduação em Educação Física, Florianópolis, 2014.Evidências recentes demonstram que o treinamento de futebol por meio de jogos reduzidos é efetivo para
Ortiz, Jaelson Gonçalves
core  

Complement Component 3 Negatively Regulates Antibody Response by Modulation of Red Blood Cell Antigen

, 2018
Red blood cell (RBC) alloimmunization can make it difficult to procure compatible RBCs for future transfusion, directly leading to increased morbidity and mortality in transfusion-dependent patients.
Connie M. Arthur, Jingchun Liu, Connie M. Arthur (5364116), Jeanne E. Hendrickson, Seema R. Patel (5364107), Sean R. Stowell (659895), Amanda Mener (5364110), Amanda Mener, Jeanne E. Hendrickson (5364113), Jingchun Liu (306275), Seema R. Patel, Sean R. Stowell   +11 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Beyond Direct Fibrinolysis: Novel Approaches to Thrombolysis

Pharmaceuticals
Fibrinolysis is a natural component of hemostasis in which a no-longer-needed clot is gradually dissolved to restore blood flow. Under pathological thrombotic conditions, this process can be pharmacologically enhanced to promote clot removal.
Alexey M. Shibeko, Nikita S. Nikitin, Nadezhda A. Podoplelova, Valentin A. Manuvera, Vassili N. Lazarev   +4 more
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

The key role of nitric oxide in hypoxia: hypoxic vasodilation and energy supply-demand matching [PDF]

Significance: a mismatch between energy supply and demand induces tissue hypoxia with the potential to cause cell death and organ failure. Whenever arterial oxygen concentration is reduced, increases in blood flow - 'hypoxic vasodilation' - occur in an ...
Feelisch, Martin, Umbrello, Michele, Dyson, Alex, Singer, Mervyn   +3 more
core   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

The effects of low-sodium peritoneal dialysis fluids on blood pressure, thirst and volume status

, 2009
Background. Poor ultrafiltration is associated with worse outcomes in peritoneal dialysis (PD) patients. This might in part reflect problems associated with salt and water excess.
Johansson, Ann-Cathrine, Chan, Cian, Venturoli, Daniele, Davies, Simon, Simonsen, Ole, Ledebo, Ingrid, Rippe, Bengt, Carlsson, Ola, Wieslander, Anders   +8 more
core   +1 more source

Remodeling of the circRNA Landscape in Myocardial Infarction Integrates Nuclear Regulation, DNA Damage Response, and Cardiomyocyte Structural Pathways

Biomolecules
Plasma circular RNAs (circRNAs) are stable RNA molecules found in blood, which makes them potential noninvasive biomarkers for acute myocardial infarction (MI).
Rudaynah Alali, Naif Khalid Alqannas, Alawi H. Habara, Mohammed Almansori, Ali Alsaeed, Chittibabu Vatte, Cyril Cyrus, Safi G. Alqatari, Hassan Albisher, Mustafa H. Al-ajwad, Faisal S. Alshahrani, Moyad M. Almuslim, Morten T. Venø, Brendan J. Keating, Amein K. Al-Ali   +14 more
doaj   +1 more source