Results 101 to 110 of about 7,178,224 (293)

Artefact removal.

, 2012
Illustration of the removal of two blink artefacts using temporal decorrelation separation independent component analysis. A: the component which contained the blink artefacts for one trial. B: the data before and after removal of the latter component.
Slawomir J. Nasuto (123250), Judi A. Ellis (123245), Patricia M. Riddell (123241), Catherine M. Sweeney-Reed (123238), Jayne E. Freeman (123248)   +4 more
core   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

The pathophysiology of fluid removal during haemodialysis: implications for blood volume monitoring and determination of dry weight. [PDF]

, 2007
The aim of the research was to characterise the pathophysiology of ultrafiltration (UF) during haemodialysis (HD) using a range of assessment tools. The hypothesis was that objective monitoring would facilitate accurate estimation of dry weight (DW) and ...
Mitra, S., Mitra, Sandip
core  

PREVENTION of TRANSFUSION-ASSOCIATED CHAGAS-DISEASE - EFFICACY of WHITE CELL-REDUCTION FILTERS in REMOVING TRYPANOSOMA-CRUZI FROM INFECTED BLOOD

, 1995
Background: Transfusion-associated Chagas' disease (TA-CD) is a worldwide problem. Measures adopted to prevent TA-CD include the clinical and serologic screening of blood donors and/or the inactivation of Trypanosoma cruzi present in collected blood ...
Blajchman, M. A., L. Bardossy, Moraessouza, H., M.A. Blajchman, Macpherson, D. W., D.W. MacPherson, J.O. Bordin, Bordin, J. O., Bardossy, L., H. Moraes‐Souza   +9 more
core   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Endotoxin Removal from Whole Blood by a Novel Adsorption Resin: Efficiency and Hemocompatibility

, 2004
The structural component of Gram- bacteria, endotoxin (ET), induces the release of endogenous mediators of sepsis. Attempts to remove these downstream molecules in vivo, have not improved survival.
N. Rajapakse, E. Hegyi, M.-C. Amoureux, P. Grandics, D. Le, S. Szathmary   +5 more
core   +1 more source

Beyond Direct Fibrinolysis: Novel Approaches to Thrombolysis

Pharmaceuticals
Fibrinolysis is a natural component of hemostasis in which a no-longer-needed clot is gradually dissolved to restore blood flow. Under pathological thrombotic conditions, this process can be pharmacologically enhanced to promote clot removal.
Alexey M. Shibeko, Nikita S. Nikitin, Nadezhda A. Podoplelova, Valentin A. Manuvera, Vassili N. Lazarev   +4 more
doaj   +1 more source

GBS‐MeDIP: A method for the simultaneous identification of genetic and epigenetic variants in tumors

FEBS Open Bio, EarlyView.
GBS‐MeDIP combines DNA sequencing with enrichment of methylated DNA to profile genetic and epigenetic variation in the same reduced genomic fraction. Applied to gastric cancer and parathyroid tumors, it identifies sequence variants, copy number changes, and differentially methylated regions together, helping distinguish true epigenetic changes from ...
Fábio Pértille, Shiva Rezaei, Julia Uffenorde, Oliver Gimm, Mohammad Ali Hosseinpour Feizi, Luiz Lehmann Coutinho, Carlos Guerrero‐Bosagna   +6 more
wiley   +1 more source

New dialysis membranes for the management of inflammation, nutrition, and immunogenicity

Giornale di Clinica Nefrologia e Dialisi
Dialysis membranes represent a key component of hemodialysis therapy, influencing not only purification efficiency but also the patient’s biological response.
Mario D'Agostino, Lucia Palma, Antonio Nicoletti, Irma Figlia   +3 more
doaj   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source