Results 121 to 130 of about 2,301,317 (358)

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Relationship of Lead Exposure with Workers\' Blood Pressure and Blood Components: A Case Study

Archives of Occupational Health, 2020
Background: Lead is one of the most widely used metals in the industries and is the amplest metal element on the Earth’s crust. This metal disrupts the physiological processes of the body due to its accumulation in various tissues.
Salman Torabi Goodarzi, Farideh Golbabaei, Bahram Harati, Robabeh Chang, Vahid Ahmadi, mohsen sadeghi yarandi   +5 more
doaj  

Indications for transfusion of donor blood components in emergency surgery

Трансплантология (Москва), 2018
In terms of complications due to allogeneic blood transfusions, it is necessary to use the latter only in accordance with the strict indications elaborated specifically for each component.
E. N. Kobzeva, E. A. Sakharova, B. A. Sorokin, V. B. Khvatov   +3 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Quality control in the different stages of producing red blood cell concentrate from dogs

Arquivo Brasileiro de Medicina Veterinária e Zootecnia
The objective of this study was to perform a quality control assessment of red blood cells after standardization of the blood production stages. For this purpose, separation of the blood components to obtain red blood cells, the storage of the blood ...
M.N.A. Marchi, P.E. Luz, R.R. Martins, S.M. Simonelli, U.P. Pereira, P.M. Pereira   +5 more
doaj   +1 more source

BLOOD TRANSFUSION IN LUNG OPERATIONS

Вестник хирургии имени И.И. Грекова, 2016
The authors admit the risks of blood transfusion, as well as the fact that the blood is a limited resource. These conclusions became the basis of the research in order to make an analysis and develop transfusion strategies in the hospital.
I. A. Pashkova, V. A. Porkhanov, I. S. Polyakov, S. D. Sitnik, M. P. Mozheiko, Z. Yu. Zueva, I. Yu. Sholin   +6 more
doaj   +1 more source

Depolarization increases cellular light transmission [PDF]

, 2008
Application of optical methods to human brain tissue in vivo, e.g., measuring oxyhemoglobin and deoxyhemoglobin concentration changes with near-infrared spectroscopy (NIRS), requires the a priori assumption that background optical properties remain ...
Haruki Toriumi, Jemal Tatarishvili, Minoru Tomita, Miyuki Unekawa, Norihiro Suzuki, Takashi Osada, Yutaka Tomita   +6 more
core   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source