Results 51 to 60 of about 1,172,469 (264)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Epidemiological and Clinical Study of Phenylketonuria (PKU) Disease in the National Screening Program of Neonates, Fars Province, Southern Iran

Iranian Journal of Public Health, 2009
Background: Classic phenylketonuria (PKU) is a rare metabolic disorder that results from a deficiency of a liver enzyme known as phenylalanine hydroxylase (PAH).
S Senemar , H Ganjekarimi , M Fathzadeh, S Senemar , B Tarami , M Bazrgar   +5 more
doaj  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Spectrum of Isolates and Antimicrobial Susceptibility Pattern from Blood Cultures in Tertiary Care Hospital, Riyadh

Journal of Pure and Applied Microbiology
Clinical presentation of bloodstream infection ranges from transitory bacteremia to fulminant septic shock with substantial mortality. Regular monitoring of bacteremia etiology helps rationalize therapy, revealing the spectrum of bacterial infections and
Fizza Khalid, Christy Poulose, Azza Elsheikh, Abid Mahmood, Osamah T. Khojah   +4 more
doaj   +1 more source

Bacteriologic Antibiography Outline of Isolates from Blood Culture at Tertiary Center

Journal of Pure and Applied Microbiology, 2020
Bacteria found in blood circulation either consistently intermittently are commination to every organs of body. These infections can affect life and death.
Dhruba Hari Chandi, Praful Patil, Smita Damke, Silpi Basak, Rangaiahagari Ashok   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

A CASE OF MYCOTIC SEPSIS DUE TO TRICHOSPORON COREMIIFORME IN A TRAUMA PATIENT IN MHAT-SHUMEN

Problems of Infectious and Parasitic Diseases
Trichosporon spp. are yeast-like fungi,a rare cause of mycotic sepsis. We share a case report of a thirty-three year old man with polytrauma after a car accident, who died after a long hospitalization and treatment in intensive care unit.
Stanislava Voycheva, Emilia Bozova, Ivva Philipova, Lyubomira Boyanova   +3 more
doaj   +1 more source

Blood culture contamination rates at different level healthcare institutions in the Western Cape, South Africa

Southern African Journal of Infectious Diseases, 2020
Sterile blood culture (BC) collection procedures are important to prevent the consequences of contamination, namely, prolonged patient hospitalisation, unnecessary antimicrobial exposure and an increase in hospital costs.
Christoffel J. Opperman, Banyana Baloyi, Sipho Dlamini, Nazlee Samodien   +3 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source