Results 71 to 80 of about 2,376,287 (312)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Pattern of Respiratory Problems in Neonates in a Level III Neonatal Care Unit with Special Reference to Pneumonia [PDF]

Indian Journal of Neonatal Medicine and Research, 2016
Introduction: Respiratory distress constitutes one of the commonest cause of morbidity and mortality in the neonatal period. It is more commonly encountered within the first 48-72 hours of life.
Aukifa Khamim Sabibahul Islam, Reeta Bora, Nibedita Paul, Sutharson Ramasamy   +3 more
doaj   +1 more source

Culture of periprosthetic tissue in blood culture bottles for diagnosing periprosthetic joint infection [PDF]

, 2019
Background: The purpose of this meta-analysis was to evaluate the diagnostic accuracy of periprosthetic tissue culture in blood culture bottles (BCB) for periprosthetic joint infection (PJI).
Li, Cheng, Ojeda-Thies, Cristina, Trampuz, Andrej   +2 more
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

A Systematic Review of Cases of Meningitis in the Absence of Cerebrospinal Fluid Pleocytosis on Lumbar Puncture [PDF]

, 2019
Background: Definitive diagnosis of meningitis is made by analysis of cerebrospinal fluid (CSF) culture or polymerase chain reaction (PCR) obtained from a lumbar puncture (LP), which may take days.
Pettigrew, Alexis, Troendle, Michelle
core   +1 more source

Bacterial pathogens and resistance causing community acquired paediatric bloodstream infections in low- and middle-income countries: a systematic review and meta-analysis [PDF]

, 2019
Background Despite a high mortality rate in childhood, there is limited evidence on the causes and outcomes of paediatric bloodstream infections from low- and middle-income countries (LMICs).
Basmaci, R, Dramowski, A, Droz, N, Ellis, S, Hsia, Y, Sharland, M   +5 more
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Spectrum of Isolates and Antimicrobial Susceptibility Pattern from Blood Cultures in Tertiary Care Hospital, Riyadh

Journal of Pure and Applied Microbiology
Clinical presentation of bloodstream infection ranges from transitory bacteremia to fulminant septic shock with substantial mortality. Regular monitoring of bacteremia etiology helps rationalize therapy, revealing the spectrum of bacterial infections and
Fizza Khalid, Christy Poulose, Azza Elsheikh, Abid Mahmood, Osamah T. Khojah   +4 more
doaj   +1 more source

Bacteriologic Antibiography Outline of Isolates from Blood Culture at Tertiary Center

Journal of Pure and Applied Microbiology, 2020
Bacteria found in blood circulation either consistently intermittently are commination to every organs of body. These infections can affect life and death.
Dhruba Hari Chandi, Praful Patil, Smita Damke, Silpi Basak, Rangaiahagari Ashok   +4 more
doaj   +1 more source

M-DC8+leukocytes - A novel human dendritic cell population [PDF]

, 1999
Dendritic cells (DC) constitute a heterogeneous leukocyte population having in common a unique capacity to induce primary T cell responses and are therefore most attractive candidates for immunomodulatory strategies.
Federle, Christine, Mayer, Elfriede, Poppe, Claudia, Rieber, Ernst Peter, Riethmüller, Gert, Schäkel, Knut   +5 more
core   +2 more sources