Results 91 to 100 of about 7,074,857 (310)

Assessing the prevalence of antimicrobial resistance among pediatric patients at Kamuzu Central Hospital, Malawi

Journal of Infection in Developing Countries
Introduction: Severe bacterial infections cause significant disease burden in developing countries, including Malawi. The situation is compounded by the scarcity of resources, inconsistent availability of antibiotics, and increasing antimicrobial ...
Agness C Chitedze, Rizine R Mzikamanda, Tarsizio Maida, Casey L McAtee, Lovemore Mapahla, Nicholas Feasey, Peter S Nyasulu   +6 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Time to positivity of Klebsiella pneumoniae in blood cultures as prognostic marker in patients with intra-abdominal infection: A retrospective study

Virulence
Klebsiella pneumoniae is a common causative pathogen of intra-abdominal infection with concomitant bacteraemia, leading to a significant mortality risk. The time to positivity (TTP) of blood culture is postulated to be a prognostic factor in bacteraemia ...
Yong-Ye Yang, I-Ting Tsai, Chung-Hsu Lai, Chih-Ping Chen, Chia‐Chi Chen, Yin-Chou Hsu   +5 more
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

The diagnostic accuracy of three rapid diagnostic tests for typhoid fever at Chittagong Medical College Hospital, Chittagong, Bangladesh. [PDF]

, 2015
OBJECTIVE: To determine the diagnostic accuracy of three rapid diagnostic tests (RDTs) for typhoid fever in febrile hospitalised patients in Bangladesh.
Iqbal, Nafiz, Maude, Richard J., Day, Nicholas P., Pan-Ngum, Wirichada, Dutta, Asok Kumar, de Jong, Hanna K., Phat, Voong Vinh, de, Jong Hanna K., Fukushima, Masako, Ghose, Aniruddha, de Jong, Hanna K, Karim, Mohammed Rezaul, Maude, Rapeephan R, Samad, Rasheda, Maude, Rapeephan R., van der Vaart, Thomas W., Dondorp, Arjen M., Wijedoru, Lalith, Parry, Christopher M., Parry, Christopher M, Mahmud, Nasir Uddin, Wiersinga, W. Joost, Hossain, Mohammed Amir, CMCH Typhoid Study Group, Duy, Pham Thanh, Sayeed, Abdullah Abu, Faiz, Mohammed Abul, Hero, Murad, van der Poll, Tom, Parry, Christopher, Nga, Tran Vu Thieu, Hasan, Mahtab Uddin, Chaudhury, Zabeen, Baker, Stephen   +33 more
core   +1 more source

Microbial Agents and Antimicrobial Resistance Patterns in Blood Cultures of Intensive Care Unit Patients: Pre- and Post-COVID-19 Pandemic Analysis

Gazi Medical Journal
Objective: This study aimed to identify the microbial agents isolated from blood cultures of intensive care unit (ICU) patients and their antibiotic resistance rates before and after the Coronavirus Disease 2019 (COVID-19) pandemic.
Berna Erdal, Bensu Baylan, Hülya Duran, Nuri Kiraz, Yavuz Uyar   +4 more
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Blood Transfusion Service Board annual report 1998

, 1998
The year under review was another difficult and challenging year for the Blood Transfusion Service Board. It was also the year in which many solid foundations were laid, which will assist in redeveloping and refocusing blood transfusion services in ...
Blood Transfusion Service Board
core  

Laboratory analyses for evaluation of platelet disorders and platelet concentrates [PDF]

, 2006
High quality of platelet analytics requires specialized knowledge and skills. It was applied to analyze platelet activation and aggregation responses in a prospective controlled study of patients with Finnish type of amyloidosis.
Javela, Kaija
core  

Rethinking Culture and Cultural Analysis

, 2013
The texts in this collection are revised versions of presentations given at the Coimbra International Conference on the Semantics of Culture emph Why ``Culture''?, held on November 24-25, 2011.

core   +1 more source