Results 101 to 110 of about 2,376,287 (312)

An affordable method to obtain cultured endothelial cells from peripheral blood [PDF]

, 2013
The culture of endothelial progenitor cells (EPC) provides an excellent tool to research on EPC biology and vascular regeneration and vasculogenesis. The use of different protocols to obtain EPC cultures makes it difficult to obtain comparable results in
Bueno Betí, Carlos, Heras, Magda, Hermenegildo, Carlos, Lázaro-Franco, Macarena, Novella del Campo, Susana, Pérez Cremades, Daniel, Sanchís, Juan   +6 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Microbial Agents and Antimicrobial Resistance Patterns in Blood Cultures of Intensive Care Unit Patients: Pre- and Post-COVID-19 Pandemic Analysis

Gazi Medical Journal
Objective: This study aimed to identify the microbial agents isolated from blood cultures of intensive care unit (ICU) patients and their antibiotic resistance rates before and after the Coronavirus Disease 2019 (COVID-19) pandemic.
Berna Erdal, Bensu Baylan, Hülya Duran, Nuri Kiraz, Yavuz Uyar   +4 more
doaj   +1 more source

Utility of surveillance blood cultures in patients undergoing hematopoietic stem cell transplantation [PDF]

, 2014
Background Surveillance blood cultures are often obtained in hematopoietic stem cell transplant (HSCT) patients for detection of bloodstream infection.
Bearman, Gonzalo M. L., Edmond, Michael B., Ghazal, Sameeh S., Stevens, Michael P.   +3 more
core   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

From Shadows to Spotlight: Enhancing Bacterial DNA Detection in Blood Samples through Cutting-Edge Molecular Pre-Amplification

Antibiotics
One of the greatest challenges to the use of molecular methods for diagnostic purposes is the detection of target DNA that is present only in low concentrations.
Martin Reinicke, Sascha Daniel Braun, Celia Diezel, Oliver Lemuth, Ines Engelmann, Theresa Liebe, Ralf Ehricht   +6 more
doaj   +1 more source

The Effect of Antibiotic Exposure and Specimen Volume on the Detection of Bacterial Pathogens in Children With Pneumonia. [PDF]

, 2017
BACKGROUND.: Antibiotic exposure and specimen volume are known to affect pathogen detection by culture. Here we assess their effects on bacterial pathogen detection by both culture and polymerase chain reaction (PCR) in children.
Adrian, Peter V, Ahmed, Dilruba, Baggett, Henry C, Brooks, W Abdullah, Deloria Knoll, Maria, DeLuca, Andrea N, Driscoll, Amanda J, Ebruke, Bernard E, Feikin, Daniel R, Gitahi, Caroline, Hammitt, Laura L, Higdon, Melissa M, Howie, Stephen RC, Kaewpan, Anek, Karani, Angela, Karron, Ruth A, Kotloff, Karen L, Levine, Orin S, Madhi, Shabir A, Mazumder, Razib, McLellan, Jessica, Moore, David P, Murdoch, David R, Mwananyanda, Lawrence, O'Brien, Katherine L, Park, Daniel E, PERCH Study Group, Prosperi, Christine, Rhodes, Julia, Saifullah, Md, Scott, J Anthony G, Seidenberg, Phil, Sow, Samba O, Tamboura, Boubou, Thea, Donald M, Zeger, Scott L   +35 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Evaluation of a new protocol for rapid identification of Streptococcus pneumoniae in blood cultures using the modified bile solubility test: Gram staining is still standing

Journal of Clinical Microbiology
This study aimed to evaluate a new protocol of the bile solubility test performed directly on the blood from positive blood culture bottles to identify Streptococcus pneumoniae rapidly.
Antoine Aupaix, Alexia Verroken, Hector Rodriguez-Villalobos   +2 more
doaj   +1 more source