Results 101 to 110 of about 7,074,857 (310)

From Shadows to Spotlight: Enhancing Bacterial DNA Detection in Blood Samples through Cutting-Edge Molecular Pre-Amplification

Antibiotics
One of the greatest challenges to the use of molecular methods for diagnostic purposes is the detection of target DNA that is present only in low concentrations.
Martin Reinicke, Sascha Daniel Braun, Celia Diezel, Oliver Lemuth, Ines Engelmann, Theresa Liebe, Ralf Ehricht   +6 more
doaj   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Unpopular Culture

This volume introduces a new concept that boldly breaks through the traditional dichotomy of high and low culture while offering a fresh approach to both: unpopular culture.

core   +1 more source

Evaluation of a new protocol for rapid identification of Streptococcus pneumoniae in blood cultures using the modified bile solubility test: Gram staining is still standing

Journal of Clinical Microbiology
This study aimed to evaluate a new protocol of the bile solubility test performed directly on the blood from positive blood culture bottles to identify Streptococcus pneumoniae rapidly.
Antoine Aupaix, Alexia Verroken, Hector Rodriguez-Villalobos   +2 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Development and evaluation of TUMS medium, a novel biphasic culture medium for isolation of Brucella spp. from patients [PDF]

Background and objectives: There are limitations in time and technique for isolation of Brucella from patients. We developed a new Brucella culture medium and evaluated its efficiency compared to BACTEC blood culture system and serology.
مالک نژاد, پرویز, حجازی, محمد جواد, پیری دوگاهه, هادی, فتح اله زاده, بهرام   +3 more
core  

Revitalizing the blood culture volume! [PDF]

, 2023
Blood cultures are undoubtedly the most critical investigation for bloodstream infections. However, insufficient blood culture volumes frequently impair diagnostic yield.
Chee, Lan Lau, Danapaul, Nabil Anaz Anzani, Abd Rahim, Yusuf Zawir, Zainulabid, Ummu Afeera, Kori, Najma, Periyasamy, Petrick   +5 more
core  

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Blood Culture Negative Endocarditis [PDF]

, 2006
The lethal disease infective endocarditis (IE) is caused by microorganisms that attack heart valves. Early diagnosis and identification of the causative agents are important for the choice of treatment.
Werner, Maria
core   +1 more source