Results 81 to 90 of about 2,376,287 (312)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Epidemiological and Clinical Study of Phenylketonuria (PKU) Disease in the National Screening Program of Neonates, Fars Province, Southern Iran

Iranian Journal of Public Health, 2009
Background: Classic phenylketonuria (PKU) is a rare metabolic disorder that results from a deficiency of a liver enzyme known as phenylalanine hydroxylase (PAH).
S Senemar , H Ganjekarimi , M Fathzadeh, S Senemar , B Tarami , M Bazrgar   +5 more
doaj  

A CASE OF MYCOTIC SEPSIS DUE TO TRICHOSPORON COREMIIFORME IN A TRAUMA PATIENT IN MHAT-SHUMEN

Problems of Infectious and Parasitic Diseases
Trichosporon spp. are yeast-like fungi,a rare cause of mycotic sepsis. We share a case report of a thirty-three year old man with polytrauma after a car accident, who died after a long hospitalization and treatment in intensive care unit.
Stanislava Voycheva, Emilia Bozova, Ivva Philipova, Lyubomira Boyanova   +3 more
doaj   +1 more source

Blood culture contamination rates at different level healthcare institutions in the Western Cape, South Africa

Southern African Journal of Infectious Diseases, 2020
Sterile blood culture (BC) collection procedures are important to prevent the consequences of contamination, namely, prolonged patient hospitalisation, unnecessary antimicrobial exposure and an increase in hospital costs.
Christoffel J. Opperman, Banyana Baloyi, Sipho Dlamini, Nazlee Samodien   +3 more
doaj   +1 more source

Laboratory Findings Associated with Positive Blood Cultures in Patients Using Intravascular Catheters [PDF]

, 2011
The use of intravascular catheter puts patients at risk for catheter-related bloodstream infection (CR-BSI). Laboratory diagnosis of CR-BSI involves blood culture and tip culture.
Triyana, S. Y. (Shofyatul)
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Antimicrobial Resistance in Hospital-acquired Bloodstream Infections among Children in a Pediatric Hospital in Bolivia

Journal of Global Infectious Diseases
Introduction: Antimicrobial resistance (AMR) is a growing threat to global public health. In hospitals, infant mortality due to bacterial sepsis is associated with AMR.
Diana Rodriguez, Shirley Equilia, Cristian Roca, Erica Ludi, Grover Espada, Zulma García, Blanca Machuca, Taryn Clark, Robert H. Gilman   +8 more
doaj   +1 more source

Limited utility of blood cultures in the management of febrile outpatient kidney transplant recipients

Journal of Microbiology, Immunology and Infection, 2017
Background/Purpose: Blood cultures for patients suspected of having bacteremia are standard practice, although several studies demonstrate that blood cultures have limited utility because of a low true-positive rate and infrequent resultant changes in ...
Kazuaki Tokodai, Noritoshi Amada, Izumi Haga, Atsushi Nakamura, Toshiaki Kashiwadate, Naoki kawagishi, Noriaki Ohuchi   +6 more
doaj   +1 more source

Antisepsis for blood culture extraction. Blood culture contamination rate.

Medicina intensiva, 2019
Blood cultures are the gold standard for the etiological diagnosis of bacteremia, though false-positive results are relatively frequent primarily due to contamination from skin flora during sample extraction. Correct skin antisepsis is important for reducing the bacterial load and opportunities for contamination.
Galleymore, PR, Sahuquillo, MG
openaire   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source