Results 51 to 60 of about 231,288 (293)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Molecular genetic characteristics and clinical significance of childhood acute lymphoblastic leukemia

Frontiers in Pediatrics
ObjectiveTo explore the molecular genetic characteristics of childhood acute lymphoblastic leukemia (ALL) and their relationships with clinical phenotypes, chromosomal abnormalities, and prognosis, so as to provide references for precise diagnosis and ...
Zhenzhen Zhu, Junchen Yan
doaj   +1 more source

Blood donation among university students: Practices, motivations, and barriers in Saudi Arabia

Avicenna Journal of Medicine, 2021
Context: Blood transfusion is an essential medical procedure conducted with various purposes to provide patients with blood needed. The procedure saves patients’ lives, as blood cannot be manufactured artificially and can only be obtained from human ...
Mohamed Salih Mahfouz, Majed Ryani, Ahmed Saleh Nawar Hamzi, Dhaifallah Abdullah Zaeri, Abdullah Abdulrahman Dahdoh, Abdulaziz Jaber Almalki, Ahmed Ali Jubran Hakami, Abdu Ahmed Abkr Aqeeli, Ibrahim Hussien Tawashi   +8 more
doaj   +1 more source

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

The management of a blood donor bitten by a snake [PDF]

, 2017
The worldwide burden of snakebite is high and venomous snakes are found in many regions of the world and are a threat to public health. In Italy, for instance, viper bites are an infrequent but not negligible event.
Catalano, Liviana, Franchini, Massimo, Liumbruno, Giancarlo M., Marano, Giuseppe, Pupella, Simonetta, Vaglio, Stefania   +5 more
core   +1 more source

Managing venous thromboembolic events in daily practise: ‘‘time is never enough’’

Monaldi Archives for Chest Disease, 2016
Pulmonary embolism is an insidious life-threatening condition. Its diagnosis represents a challenging topic in daily clinical practice since the recognition and the appropriate management of the condition can lead to the decrease of potentially fatal ...
D. Anyfantakis, E.K. Symvoulakis, I. Mitrouska   +2 more
doaj   +1 more source

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul, Jatuporn Sujjitjoon, Pa‐thai Yenchitsomanus, Kridtin Jarutatsanangkoon, Ng Wei Loon, Kleebsabai Sanpakit, Jassada Buaboonnam, Chayamon Takpradit, Pornpimon Yuti, Nunghathai Sawasdee, Piriya Luangwattananun, Siripakorn Sangkitporn, Arnan Limmahachai, La‐ongsri Atchaneeyasakul   +13 more
wiley   +1 more source

Comparative study of the walk-in and appointment mode of apheresis platelets donation in Guangzhou

Zhongguo shuxue zazhi, 2022
Objective To discuss the influence of apheresis platelets donation mode transformation, from walk-in to appointment, on apheresis platelets donation, donor retention and donation service quality. Methods The comparative research method is used to compare
Xiaowen CHEN, Yujian LIU, Xiaofan LI, Bi ZHONG, Jun REN, Fanhai LI, Qiwen LIN, Yongshui FU, Huiyou CHEN   +8 more
doaj   +1 more source

Outcomes of Live Virus Vaccination in Patients With Vascular Anomalies Being Treated With Sirolimus

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Live vaccination in patients with vascular anomalies (VA) receiving sirolimus remains controversial due to immunosuppressive effects and theoretical risks. Procedure This single‐center retrospective study included patients with VA less than 4 years old at the start of sirolimus therapy who were incompletely vaccinated.
Svatava Merkle, Kiersten Ricci, Kelly Blache, Rebecca A. Marsh, Adrienne M. Hammill, Elissa Engel   +5 more
wiley   +1 more source

Is removing blood donation barriers a donation facilitator? Australian African migrants’ view

, 2015
Purpose – The aim of this study was to assess whether the removal of blood donation “barriers” facilitates blood donation intentions, using a sample of African migrants, and to identify the implications for social marketing.
Francis, Kate, Polonsky, Michael, Renzaho, Andre   +2 more
core   +1 more source