Results 161 to 170 of about 356,868 (313)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

A study of the iron and HFE status of blood donors, including a group who failed the initial screen for anaemia [PDF]

, 2000
Frank Boulton, Collis, Hazel Inskip, Paes, Garlick   +4 more
openalex   +1 more source

Assessment of Liver Functions Parameters of Asymptomatic Apparently Healthy Hepatitis B Virus Carriers among Voluntary Blood Donors in Some Parts of Nigeria

, 2022
Kingsley Kalawari Odiabara, Ebirien-Agana Samuel Bartimaeus, E. O. Nwachuku, Ndokiari Boisa   +3 more
openalex   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Lower Incidence of Parvovirus-B19 Infections in Dutch Blood Donors during SARS-CoV-2 Pandemic

Microbiology Spectrum, 2021
M. W. Molenaar-de Backer, B. M. Hogema, M. H. Koppelman, T. J. van de Laar, E. Slot, H. L. Zaaijer   +5 more
doaj   +1 more source

Surface-enhanced Raman spectroscopy for the forensic analysis of vaginal fluid [PDF]

, 2016
Vaginal fluid is most often found at crime scenes where a sexual assault has taken place or on clothing or other items collected from sexual assault victims or perpetrators.
Zegarelli, Kathryn Anne
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Prevalence and Factors Associated with transfusion-transmissible infections among blood donors in Arua regional blood bank, Uganda

BMC Infectious Diseases
Background Blood transfusion services play a very key role in modern health care service delivery. About 118.5 million blood donations were collected globally in 2022.
Norman Cwinyaai, Denis Opio, Henry Kajumbula, Jane F. Zalwango, Rebecca Akunzirwe, Tom Okello, Anguzu Francis   +6 more
doaj   +1 more source

Replication Data for: Temporal trends of SARS-CoV-2 seroprevalence in transfusion blood donors during the first wave of the COVID-19 epidemic in Kenya

, 2021
Ifedayo Adetifa, Sophie Uyoga, John N. Gitonga, Mark Otiende, James Nyagwange, Henry Karanja, James Tuju, Perpetual Wanjiku, Rashid Aman, Mercy Mwangangi, Patrick Amoth, Kadondi Kasera, Wangari Ng’ang’a, Charles Rombo, Christine Yegon, Khamisi Kithi, Elizabeth Odhiambo, Thomas Rotich, Irene Orgut, Sammy Kihara, Christian Bottomley, E. Wangeci Kagucia, Katherine E. Gallagher, Anthony Etyang, Shirine Voller, Teresa Lambe, Daniel Wright, Edwine Barasa, Benjamin Tsofa, Philip Bejon, Lynette Isabella Ochola‐Oyier, Ambrose Agweyu, J. Anthony G. Scott, George M. Warimwe   +33 more
openalex   +1 more source