Results 111 to 120 of about 365,525 (310)

Exploration of the Healthy Donor Effect Among 0.6 Million Blood Donors in China: Longitudinal Study

open access: yesJMIR Public Health and Surveillance
BackgroundThe World Health Organization emphasizes the importance of completely voluntary blood donation to maintain safe and sustainable blood supplies.
Shu Su   +12 more
doaj   +1 more source

Screening Blood Donors for Human Immunodeficiency Virus Antibody: Cost-Benefit Analysis

open access: yes, 1988
The costs and benefits of screening blood donors for antibody to human immunodeficiency virus (HIV) are assessed. Total costs, including testing, discarding processed blood, marginal donor recruiting, notifying and evaluating positive donors, are $36 ...
Eisenstaedt, Richard S.   +1 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Motivating Altruism: A Field Study [PDF]

open access: yes
This paper analyzes the effects of a legislative provision that grants a one-day paid leave of absence to blood donors who are employees in Italy. The analysis is based on a unique dataset with the complete donation histories of the blood donors in an ...
Lacetera, Nicola, Macis, Mario
core  

Performance of Chemiluminiscence Assay using Reverse Algorithm for Syphilis Screening in Blood Donors

open access: yes, 2018
Better screening tests for syphilis are required to help ensure safer blood supply. Reverse screening for syphilis using specific test like chemiluminescence immunoassay (CLIA) allows automation for high sample load testing, followed by testing of ...
Subhashish Das   +3 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Blood Donors Deferral- Causes

open access: yesJournal of Rawalpindi Medical College, 2013
Background: To determine the frequency and reasons of rejection of blood donors. Methods: In this descriptive study the evaluation of blood donors was carried out for jaundice,anaemia, malaria, ulcers, diabetes, syphilis, tuberculosis, rheumatic fever ...
Samina Tufail
doaj  

The prevalence of HIV among blood donors at Juba Teaching Hospital Blood Bank, South Sudan

open access: yes, 2014
Objectives The aim of this study is to determine the prevalence of HIV among blood donors in Juba Teaching Hospital Blood Bank, South Sudan in 2013.
Rose P Gore   +10 more
core  

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