Results 121 to 130 of about 365,525 (310)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Emotional States of Blood Donors and Non-blood Donors

Blood donation constitutes a critical component of health care systems, supporting life-saving treatments and enhancing population health worldwide. The only source of blood is voluntary donations. The constant demand for secure blood supplies, especially for patients with rare blood groups and in times of emergency, emphasizes the significance of ...
Mandeep, Kumar, Shashi, Rashmi
openaire   +1 more source

Recruiting and retaining young people as voluntary blood donors [PDF]

, 2008
Objectives Reasons for predonation deferral of young potential donors and prospects of recruiting and retaining young people (age 18-29) as voluntary blood donors were studied.
Aksel H Misje, H E Heier, Blood Bank, A H Misje, V Bosnes   +4 more
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Efforts to link HIV-positive and high-risk blood donors to HIV testing, and treatment services, Mozambique, 2019–2020

Scientific Reports
Mozambique’s National Blood Transfusion Services (NBTS) is tasked with providing safe and available blood but also conducting systematic screening of at-risk potential donors, notifying seropositive blood donors, and linking them to HIV care and ...
Udhayashankar Kanagasabai, Leonardo Sousa, Michelle S. Chevalier, Steve Gutreuter, Dina Ibraimo, Sara Salimo, Eva Naueia, Laison Daniel, Selma Khan, Dawud Ujamma, Stephanie Behel, Inacio Malimane, Bakary Drammeh   +12 more
doaj   +1 more source

Surveillance of HIV-1 genetic subtypes and diversity in the US blood supply

, 2000
BACKGROUND: Recent reports of variant (non-subtype B) HIV infections in US populations have raised concerns about the sensitivity of subtype B virus-based donor screening and diagnostic assays.
Finlayson, T., Gwinn, M., Busch, M. P., Sullivan, M. T., Oliveira, C. F. de, Machado, D. M., Kessler, D., Lackritz, E. M., Operskalski, E. A., Williams, A. E., Mosley, J. W., Diaz, R. S.   +11 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Results of Serologic Screening Tests from Blood Donors at One University Hospital-based Blood Bank during 2006∼2008 [PDF]

, 2009
Background: Any data on the prevalence of the infectious diseases of blood donors at a university hospital-based blood bank is not available. We aimed to analyze the seroincidence of screening tests from blood donors at a university hospital-based blood ...
김현옥, 김현숙
core  

Predicting blood donation intentions and behavior among Australian blood donors: Testing an extended theory of planned behavior model

, 2009
BACKGROUND: Donor retention poses a significant problem to blood collection agencies around the world. Previous research using an augmented theory of planned behavior (TPB) approach has demonstrated that attitude, subjective norm, self-efficacy, moral ...
White, K., Terry, Deborah. J., K. Hyde, Melissa, White, Katherine M, White, Katherine. M., Katherine M. White, Hyde, M., Barbara M. Masser, J. Terry, Deborah, Terry, Deborah, Robinson, Natalie G, Terry, Deborah J., Masser, Barbara M., Terry, Deborah J, White, Katherine M., Natalie G. Robinson, G. Robinson, Natalie, Hyde, Melissa K, Masser, Barbara M, Robinson, N., Hyde, Melissa K., M. Masser, Barbara, Masser, B., Deborah J. Terry, Melissa K. Hyde, M. White, Katherine, Robinson, Natalie. G., Robinson, Natalie G.   +27 more
core   +1 more source