Results 181 to 190 of about 622,995 (315)

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Gender difference among blood donors: should laboratory ranges be changed? [PDF]

Blood Transfus
Pasca S, Secchi S, Postal L, Boccagni P.
europepmc   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Guidance on the management of asymptomatic blood donors who test positive for Babesia. [PDF]

Clin Infect Dis
Bloch EM, Jacobs JW, Vannier E, Wormser GP, Gelfand JA, Sikand VK, Heller HM, Sood SK, Kirkman L, Johnson JE, Marcos LA, Lemieux JE, Smith RP, Woolley AE, Perry WA, Polgreen PM, Beekmann SE, Sullivan DJ, Auwaerter PG, Krause PJ.   +19 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Immunity gap for measles in young adults: Seroprevalence study in blood donors in southern Italy. [PDF]

Hum Vaccin Immunother
Centrone F, Melilli R, Colella V, Latela A, Marziani A, Lattarulo S, Ostuni A, Sallustio A, Chironna M.   +8 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

The different barriers to donating plasma in plasma donors, whole blood donors, and non-donors in the United Kingdom. [PDF]

Transfusion
Desai R, Mills R, Masser B, Jones T, Edwards T, Brailsford SR, O'Hagan N, Washington C, Ferguson E.   +8 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Seroprevalence of celiac disease antibodies in blood donors. [PDF]

Qatar Med J
Saddique MU, Abdelmola AAA, Hmissi SMM, Alaboudy A, Chandra P, Derbala MFM.   +5 more
europepmc   +1 more source