Results 191 to 200 of about 622,995 (315)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Prevalence and pattern of transfusion transmitted infections among blood donors visiting a tertiary care hospital, Pakistan. [PDF]

BMC Infect Dis
Iqbal K, Farhad S, Khan MSA, Jan MH, Khan IZ, Umair M, Hassan B, Hotak R.   +7 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

West Nile Virus: Seroprevalence and Epidemiological Study in Blood Donors in North Central Anatolia Amid Global Threats. [PDF]

J Med Virol
Gureser AS, Karasartova D, Kosar-Askin N, Taylan-Ozkan A.   +3 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Tickborne Neoehrlichia mikurensis in the Blood of Blood Donors, Norway, 2023. [PDF]

Emerg Infect Dis
Quarsten H, Ryen CNB, Mørk LKT, Wennerås C, Steinsvåg CT.   +4 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Global burden of asymptomatic malaria among blood donors: systematic review and meta-analysis. [PDF]

BMC Infect Dis
Malede B, Amare GA, Setegn A, Fenta A, Mengist A, Belew H, Muche Y, Abebaw D, Melkamu A, Ashagre A, Jemal M, Teffera ZH, Belayneh M, Abebaw A, Getinet M, Wondmagegn M, Abeje G, Almaw A, Berhan A, Adugna A, Admasu A, Wondimu H, Misganaw T, Wondmagegn YM.   +23 more
europepmc   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

The HLA landscape of Colombia: a high-resolution analysis of 11,576 blood donors. [PDF]

Front Immunol
Muñoz AL, Uricoechea D, Gómez LA, Argote-Bérdugo H, Bula J, Rueda MA, Rueda MG, Briceño I.   +7 more
europepmc   +1 more source