Results 81 to 90 of about 6,138,867 (237)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Blood flow in humans following low-load exercise with and without blood flow restriction

, 2017
Blood flow restriction (BFR) in combination with exercise has been used to increase muscle size and strength using relatively low loads (20%–30% 1-repetition maximum (1RM)).
Kevin T. Mattocks, Matthew B. Jessee, Scott J. Dankel, Samuel L. Buckner, Gilberto C. Laurentino, Brittany R. Counts, J. Grant Mouser, Jeremy P. Loenneke   +7 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Effects of Blood Flow Restriction Combined with Aerobic Stepping Exercise in Sarcopenia: A Study Protocol for a Randomized Clinical Trial [PDF]

Hui Zhang,1,2 Mengli Li,3 Zhiyu Mao,2 Tongtong Yin,2 Jiaying Qi,2 Fangfang Wang,2 Li Wang2 1School of Nursing, Suzhou Vocational Health College, Suzhou, Jiangsu, 215009, People’s Republic of China; 2School of Nursing, Suzhou Medical College of Soochow ...
Qi J, Yin T, Zhang H, Wang F, Li M, Mao Z, Wang L   +6 more
core  

Fetal liver blood flow distribution: role in human developmental strategy to prioritize fat deposition versus brain development [PDF]

, 2012
Among primates, human neonates have the largest brains but also the highest proportion of body fat. If placental nutrient supply is limited, the fetus faces a dilemma: should resources be allocated to brain growth, or to fat deposition for use as a ...
Crozier, SR, Sarah R. Crozier, Sian M. Robinson, Guttorm Haugen (141243), Sarah R Crozier, Kiserud, T., Hanson, M.A., Inskip, H.M., Haugen Guttorm, Nicholas C. W. Harvey, Harvey Nicholas C. W., Crozier Sarah R., Haugen, G., Hazel M. Inskip, Robinson Sian M., Crozier, S.R., Inskip, HM, Mark A. Hanson (114427), Cyrus Cooper (141250), Godfrey, Keith M., Sian M Robinson, Mark A Hanson, Cyrus Cooper, Cooper Cyrus, Lucy Davies, Harvey, NC, Hazel M. Inskip (141248), Haugen, G, Guttorm Haugen, Harvey, N.C., Godfrey Keith M., Kiserud, T, Robinson, S.M., Mark A. Hanson, Keith M Godfrey, Nicholas C W Harvey, Hanson Mark A., Torvid Kiserud, Southampton Women's Survey Study Group, Cooper, Cyrus, Davies, L, Hanson, MA, Sarah R. Crozier (141254), Keith M. Godfrey, Inskip Hazel M., Godfrey, KM, Hazel M Inskip, Sian M. Robinson (141258), Kiserud Torvid, Keith M. Godfrey (141238), Cooper, C., Robinson, SM, Davies Lucy, Cooper, C, Torvid Kiserud (141246), Lucy Davies (141261), Davies, L., Nicholas C. W. Harvey (141252)   +57 more
core   +1 more source

Effects of aerobic exercise with blood flow restriction on cardiorespiratory and functional capacity in the elderly: a systematic review

Acta Scientiarum. Health Sciences
This study systematically reviewed the available scientific evidence regarding the chronic changes promoted by aerobic exercise (AE) combined with blood flow restriction (BFR) on cardiorespiratory capacity (CC) and functional capacity (FC) in the ...
Edgleisson Almeida da Silva , Gabriel Filipe Barboza Cavalcanti, João Paulo Carvalho Lima, Theodan Stephenson Cardoso Leite, Jean Paulo Guedes Dantas, Gabriel Rodrigues Neto   +5 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source