Results 41 to 50 of about 1,011,739 (356)

Automatic Estimation of Coronary Blood Flow Velocity Step 1 for Developing a Tool to Diagnose Patients With Micro-Vascular Angina Pectoris

Frontiers in Cardiovascular Medicine, 2019
Aim: Our aim was to automatically estimate the blood velocity in coronary arteries using cine X-ray angiographic sequence. Estimating the coronary blood velocity is a key approach in investigating patients with angina pectoris and no significant coronary
Mahdieh Khanmohammadi, Kjersti Engan, Charlotte Sæland, Trygve Eftestøl, Alf I. Larsen, Alf I. Larsen   +5 more
doaj   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

A study of effects of heat source on MHD blood flow through bifurcated arteries

AIP Advances, 2011
An analytical study of effect of heat source on MHD blood flow through bifurcated arteries has been done. The blood flowing through arteries is treated to be unsteady Newtonian flow.
Om Prakash, S. P. Singh, Devendra Kumar, Y. K. Dwivedi   +3 more
doaj   +1 more source

Cerebral blood flow velocity in sleep

Perspectives in Medicine, 2012
SummarySleep is the most conspicuous alteration of cerebral function during the circadian rhythm. It is composed of a cyclic sequence of stages defined on the basis of electrophysiological parameters. The underlying functional activity of the human brain is reflected by sleep correlated changes of cerebral blood flow (CBF), CBF velocity and cerebral ...
openaire   +2 more sources

Transcranial Doppler measurement of middle cerebral artery blood flow velocity: a validation study.

Stroke, 1986
Measurement of intracranial arterial blood flow velocity is a new technique with potentially a number of very useful applications. This study validates the technique by comparing it to cerebral blood flow (CBF) measured using intravenous Xenon133 and ...
C. C. R. Bishop, S. Powell, D. Rutt, N. Browse   +3 more
semanticscholar   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Increased macular choroidal blood flow velocity during systemic corticosteroid therapy in a patient with acute macular neuroretinopathy

Clinical Ophthalmology, 2012
Yuki Hashimoto,1 Wataru Saito,1,2 Shohei Mori,1 Michiyuki Saito,1 Susumu Ishida1,21Department of Ophthalmology, 2Department of Ocular Circulation and Metabolism, Hokkaido University Graduate School of Medicine, Sapporo, JapanPurpose: The precise ...
Hashimoto Y, Saito W, Mori S, Saito M, Ishida S   +4 more
doaj  

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

A Deep Neural Network Method for Arterial Blood Flow Profile Reconstruction

Entropy, 2021
Arterial stenosis will reduce the blood flow to various organs or tissues, causing cardiovascular diseases. Although there are mature diagnostic techniques in clinical practice, they are not suitable for early cardiovascular disease prediction and ...
Dan Yang, Yuchen Wang, Bin Xu, Xu Wang, Yanjun Liu, Tonglei Cheng   +5 more
doaj   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source