Results 191 to 200 of about 39,802 (287)

Pubertal Timing Associates With Cardiometabolic Markers During Puberty and in Young Adulthood

Acta Paediatrica, EarlyView.
ABSTRACT Aim To study how pubertal timing associates with cardiometabolic measures in puberty and young adulthood. Methods Cardiovascular risk factors, anthropometry and pubertal development were regularly studied in STRIP study subjects until age 26 years.
Saga Nummela, Katja Pahkala, Sinikka Karppinen, Jorma Toppari, Olli Raitakari, Jorma Viikari, Tapani Rönnemaa, Harri Niinikoski   +7 more
wiley   +1 more source

Importance of blood glucose meter and carbohydrate estimation accuracy. [PDF]

J Diabetes Sci Technol, 2012
Virdi NS, Mahoney JJ.
europepmc   +1 more source

Metabolic Risk Factors Are Associated With Weight Status Change Over Four Years in Children Aged 4–6 Years With Obesity

Acta Paediatrica, EarlyView.
ABSTRACT Aim It is unclear how early childhood obesity treatment affects metabolic risk. This study assessed long‐term metabolic health in children with obesity aged 4–6 years and examined associations with weight status. Methods This prospective cohort study pooled data from the Sweden‐based More and Less randomized controlled trial, which compared a ...
Markus Brissman, Anna Ek, Stella Wennborg, Karin Nordin, Karin Eli, Annika Janson, Paulina Nowicka   +6 more
wiley   +1 more source

A study of patient experience using a blood glucose meter with an in-built insulin dose calculator. [PDF]

J Diabetes Sci Technol, 2014
Ramtoola S, Jude E, Robinson A, Malik I, Rayman G, Dang C, RossMartin GD, Ali A.   +7 more
europepmc   +1 more source

Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries

British Journal of Pharmacology, EarlyView.
Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley   +1 more source

Neurokinin‐1 receptor activation protects against cardiac fibrosis, inflammation and diastolic dysfunction in type 2 diabetic mice

British Journal of Pharmacology, EarlyView.
Background and Purpose The pathogenesis of type 2 diabetes mellitus (T2DM)‐induced cardiomyopathy involves cardiac fibrosis that leads to diastolic dysfunction. We established that replacement of lost substance P (SP) that occurs in T2DM reduces cardiac fibrosis and decreases inflammation in T2DM mice and non‐human primates.
Alexander Widiapradja, Heather Connery, Brody J. Helmick, Kallie J. Schafner, Vamsi Manchikalapudi, Hannah Horvath, Sophia Gugino, Tamas Kriska, Anja Herrnreiter, Evan DeVallance, William B. Campbell, Scott P. Levick   +11 more
wiley   +1 more source

Biomimetic MCC950‐loaded cerium‐layered double hydroxide nanoparticles for targeted treatment of Type 1 diabetes in streptozotocin‐induced mice

British Journal of Pharmacology, EarlyView.
The CLMBM nanoparticle (NP) system demonstrates strong and targeted anti‐ROS, antiapoptotic and anti‐inflammatory properties within the pancreas, thereby inhibiting the onset and progression of type 1 diabetes. Background and Purpose The destruction of β‐cells in type 1 diabetes is driven by signalling cascades that ultimately lead to cell apoptosis ...
Huiwen Pang, Zhuo Chen, Youzhi Wu, Thanh‐Truc Nguyen, Jingjing Wang, David M. Klyne, Zhi Ping Xu, Chen Chen, Alan Rowan, Felicity Y. Han   +9 more
wiley   +1 more source

AMPK‐mediated prevention of vascular dysfunction with metformin: Experimental and population‐based evidence

British Journal of Pharmacology, EarlyView.
Angiotensin II induces vascular inflammation, senescence, extracellular matrix (ECM) degradation and endothelial dysfunction, thus impairing SK+/IK+ channel function and reducing endothelial‐dependent hyperpolarisation (EDH). Metformin activates AMPK, increasing SK+/IK+ channel function and restoring vasorelaxation.
Soroush Mohammadi Jouabadi, Annika A. Jüttner, Annique Claringbould, Rene de Vries, Ingrid M. Garrelds, Usha Musterd‐Bhaggoe, Bruno H. Stricker, Maryam Kavousi, A. H. Jan Danser, Fariba Ahmadizar, Anton J. M. Roks   +10 more
wiley   +1 more source

Obesity in Classic Congenital Adrenal Hyperplasia: Mechanisms, Complications and Management

Clinical Endocrinology, EarlyView.
ABSTRACT Classic congenital adrenal hyperplasia (CCAH) is an autosomal recessive genetic disorder primarily caused by 21‐hydroxylase deficiency. Although the survival rate of patients has significantly improved with glucocorticoid replacement therapy, long‐term use of supraphysiological doses and multiple factors inherent to the disease itself have led
Jialin Mu, Yue Li, Meng Sun, Yulin Li, Panpan Li, Hui Zou   +5 more
wiley   +1 more source

Input Visualizations to Track Health Data by Older Adults with Multiple Chronic Conditions

Computer Graphics Forum, EarlyView.
Abstract Older adults living with multiple chronic conditions (MCC) can considerably benefit from collecting and reflecting on their health data. Many older adults collect their health data using various approaches, such as digital tools or handwritten notebooks.
Shri Harini Ramesh, Foroozan Daneshzand, Matteo Sotelo, Mahsa Sinaei, Fateme Rajabiyazdi   +4 more
wiley   +1 more source