Results 101 to 110 of about 7,093,189 (263)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
The association between childhood blood lead levels and proximity to airports in Colorado
Discover EnvironmentBackground In October 2023, the U.S. Environmental Protection Agency announced a final endangerment finding that leaded aviation gasoline (avgas) contributes to air pollution that is harmful to public health.
Kevin Berg +2 more
doaj +1 more source
Lead Poisoning in the Americas: Sources, Regulations, Health Impacts, and Molecular Mechanisms
Journal of XenobioticsLead poisoning is a significant public health issue, contributing to 0.6% of the global disease burden and disproportionately affecting developing countries.
Blanca Miriam Torres-Mendoza +11 more
doaj +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Guidelines for measuring lead in blood using point of care instruments [PDF]
This document was solely produced by the Advisory Committee for Childhood Lead Poisoning Prevention and adopted with one abstention on July 25, 2013. The posting of this document to our website in no way authorizes approval or adoption of the guidelines ...
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A spatial analysis of Muncie's soils and playground dust associated with elevated blood lead levels
, 2023 This research synthesized findings from three studies investigating environmental lead (Pb) contamination in various environments in Muncie, Indiana, exploring the interaction of Pb with socio-economic conditions, soil properties, and Pb presence in ...
Elnajdi, Abdulgadir Ahmad
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FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Blood Transfusion Service Board annual report 1998
, 1998 The year under review was another difficult and challenging year for the Blood Transfusion Service Board. It was also the year in which many solid foundations were laid, which will assist in redeveloping and refocusing blood transfusion services in ...
Blood Transfusion Service Board
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