Results 111 to 120 of about 7,093,189 (263)
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Blood lead levels in children [PDF]
Lead exposure occurs when a child comes in contact with lead by swallowing or breathing in lead or lead dust. After a child inhales or swallows lead, it quickly enters the blood. No safe blood level in children has been identified.
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FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
Monetary benefits of preventing childhood lead poisoning with lead-safe window replacement [PDF]
Previous estimates of childhood lead poisoning prevention benefits have quantified the present value of some health benefits, but not the costs of lead paint hazard control or the benefits associated with housing and energy markets. Because older housing
Berg, Michael +3 more
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Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
"This is the fifth revision of Preventing Lead Poisoning in Young Children by the Centers for Disease Control and Prevention (CDC). As with the previous statements, the recommendations presented here are based on scientific evidence and practical ...
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Decline in blood lead testing in young children following the onset of the COVID-19 pandemic [PDF]
cdc:103009cdc-decline-in-testing-blood-lead-rates-during-covid-pandemic-508 ...
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Individualized support for breastfeeding in a case of elevated blood lead levels: A case report
Toxicology ReportsIntroduction: Lead is a known toxicant that affects all tissues in the body, most notably the brains of developing children. However, there are limited data on the dynamics of lead transfer via breastmilk and its short-term and long-term consequences ...
Ashley Wallace Wu +2 more
doaj +1 more source
Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix
FEBS Letters, EarlyView.The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual +3 more
wiley +1 more source
BLOOD LEAD TESTING IN PUBLIC HEALTH LABORATORIES : AN APHL SURVEY REPORT [PDF]
In February 2019, APHL distributed a survey on the pediatric blood lead testing programs at US public health laboratories (PHLs). Distributed as an electronic questionnaire, the survey informed APHL and its members on current pediatric lead testing ...
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