Results 111 to 120 of about 15,095,533 (296)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Expansion of recall of LeadCare blood lead tests due to risk of falsely low results [PDF]

Distributed via the CDC Health Alert NetworkOctober 14, 2021, 10:00 AM ETCDCHAN-00454Magellan Diagnostics, Inc. and the U.S. Food and Drug Administration (FDA) have issued notifications about the expansion of Magellan Diagnostics\u2019 recall of LeadCare

core  

Blood lead level evaluation in children presenting with chronic constipation in Tehran-Iran: a cross-sectional study. [PDF]

Sci Rep, 2023
Zamani N, Hosseini A, Farnaghi F, Sayyari A, Gholami N, Imanzadeh F, Hadeiy SK, Hajipour M, Salimi A, Philips S, Hassanian-Moghaddam H.   +10 more
europepmc   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

"Blood lead level among battery factory workers in low and middle-income countries: Systematic review and meta-analysis". [PDF]

Front Public Health, 2022
Olana AT, Kumie A, Abegaz T.
europepmc   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Blood lead level in Chinese adults with and without coronary artery disease. [PDF]

J Geriatr Cardiol, 2021
Li SH, Zhang HJ, Li XD, Cui J, Cheng YT, Wang Q, Wang S, Krittanawong C, El-Am EA, Bou Chaaya RG, Wu XY, Gu W, Liu HH, Yan XL, Li ZZ, Yang SW, Sun T.   +16 more
europepmc   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Amelioration of intestinal barrier function and reduction of blood lead level in adult women with recurrent spontaneous abortion by a novel product of dietary fiber mixture, Holofood. [PDF]

J Health Popul Nutr, 2023
Tian Y, Pan Z, Lan L, Chang Y, Zhao T, Fu Z, Wu S, Deng T, Cao M, Wang W, Bi Y, Yang R, Yang Lee BJ, Liu Q.   +13 more
europepmc   +1 more source