Results 131 to 140 of about 1,492,573 (300)

Blood lead level in the US population 1999-2012

, 2015
OBJECTIVE: Chronic low-level exposure to lead is thought to be associated with increased blood pressure in adults. Therefore, we analyzed the latest trends in blood lead level in the US population.
Cheung, AJ, Tsoi, MF, Cheung, TT, Cheung, BMY   +3 more
core  

Blood lead levels and increased bronchial responsiveness.

, 2008
The immune system is one of the targets most sensitive to lead toxicity, and the association between lead exposure and serum immunoglobulin E (IgE) has been published. Recent studies also reported that lead caused the development of IgE-mediated allergy.
Paek, D, Min, KB, Rokho Kim, Kyoung-Bok Min, Domyung Paek, Min, JY, Kim, R, Jin-Young Min, Sung-Il Cho, Cho, SI   +9 more
core   +1 more source

Blood Lead Level Is Negatively Associated With Bone Mineral Density in U.S. Children and Adolescents Aged 8-19 Years. [PDF]

Front Endocrinol (Lausanne), 2022
Cui A, Xiao P, Hu B, Ma Y, Fan Z, Wang H, Zhou F, Zhuang Y.   +7 more
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Blood Lead Level in a Paediatric Population of South-Eastern Spain and Associated Risk Factors. [PDF]

Int J Environ Res Public Health, 2021
Ruiz-Tudela L, Vázquez-López MA, García-Escobar I, Cabrera-Sevilla JE, Gómez-Bueno S, Martín-Gonzalez M, Muñoz-Vico FJ.   +6 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Blood lead level and risk of hypertension in the United States National Health and Nutrition Examination Survey 1999-2016. [PDF]

Sci Rep, 2021
Tsoi MF, Lo CWH, Cheung TT, Cheung BMY.
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Lead Service Lines and Infant Blood Lead Levels

JAMA Network Open
This cross-sectional study investigates whether living in a residence with a lead service line is associated with blood lead levels among infants.
Balza, Joanna, Dawson, Aprill Z., Nelson, David, Kaeppler, Caitlin, Cusatis, Rachel, Flynn, Kathryn E.   +5 more
openaire   +3 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source