Results 141 to 150 of about 15,095,533 (296)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Blood lead level and correlation with pregnancy-associated anaemia [PDF]

, 2018
BackgroundThe most common reason that leads to anaemia is related to the reduction in certain trace elements such as Fe. However, it has been found that an elevation in some other heavy metals such as Pb could also lead to anaemia.AimsThis research aims ...
Adnan Massadeh; Jordan University of Science and Technology, Yousef Khader; Jordan University of Science and Technology, Wafa Sbuihat; Jordan University of Science and Technology, Shereen Hamadneh; Al-Albayt University, Jehan Hamadneh; Jordan University of Science and Technology, Manal Kassab; Jordan University of Science and Technology, Nahla Al-bayyari; Al-Huson University College, Balqa Applied University   +6 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Blood Lead Level among Children between 8-18 years of Age by Atomic Absorption Spectrophotometry: A Descriptive Cross-sectional Study. [PDF]

JNMA J Nepal Med Assoc, 2021
Shrestha YK, Khanal MP, Shrestha SK, Shrestha J, Shrestha N.   +4 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Persistent lead neurotoxicity as a consequence of global regulatory failure and trade-driven exposure inequities

Discover Public Health
Background The global phase-out of leaded gasoline, completed in 2021, is widely regarded as a major public health success. However, this achievement has fostered policy complacency, while legacy reservoirs and emerging exposure vectors continue to ...
Naveen Kumar Rajasekaran, Chetan Ashok, Srikanth Jeyabalan, Gayathri Veeraraghavan, Vetriselvan Subramaniyan, Devaraja Dravida Pandiyan S, Ling Shing Wong, Mahendran Sekar, Ravindran Jaganathan   +8 more
doaj   +1 more source

Beta-Adrenergic Receptor Density and Adenylate Cyclase Activity in Lead- Exposed Rat Brain after Cessation of Lead Exposure

, 2008
To understanding the reversible or irreversible harm to the beta- adrenergic system in the brain of lead-exposed rats, this study sets up an animal model to estimate the change in the sympathetic nervous system of brain after lead exposure was withdrawn.
CHANG, HUOY-ROU;TSAO, DER-AN;YU, HSIN- SU;HO, CHI-KUNG, 張慧柔;曹德安;余幸司;何啟功   +1 more
core  

Reassessment of the threshold of the blood lead level to increase urinary δ-aminolevulinic acid based on their relationship in recent lead workers in Japan. [PDF]

J Occup Health, 2021
Ono A, Horiguchi H.
europepmc   +1 more source