Results 121 to 130 of about 15,095,533 (296)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

open access: yesFEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise   +5 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

open access: yesFEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward   +2 more
wiley   +1 more source

Blood lead levels in children [PDF]

open access: yes
Lead exposure occurs when a child comes in contact with lead by swallowing or breathing in lead or lead dust. After a child inhales or swallows lead, it quickly enters the blood. No safe blood level in children has been identified.

core  

Blood lead level in patients with irritable bowel syndrome

open access: yes, 2019
Background: Irritable bowel syndrome and elevated blood lead level share certain gastrointestinal symptoms. Objective: We measured blood lead levels in IBS patients, comparing them with IBS severity.
Shahbazi, S.   +3 more
core   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

open access: yesFEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual   +3 more
wiley   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

open access: yesFEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng   +8 more
wiley   +1 more source

Blood Lead Level of Workers in a Printing Industry

open access: yesArchives of Occupational Health, 2019
Background: Different chemical materials especially inks are used in printing industry and lead is one of the ingredients that make up its pigments.
Zhaleh Sedghi Noushabadi   +3 more
doaj  

The Relation Between Blood Lead Levels and Osteoporosis in Turkish Women

open access: yes, 2004
Lead is a toxic heavy element which is to 90% deposited in bone until the 6th decade and is given to the blood with pregnancy, lactation and physiologic osteoporosis.
Derviş Özçelik   +6 more
core  

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