Results 81 to 90 of about 1,061,550 (298)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

A theoretical study of the response of vascular tumours to different types of chemotherapy [PDF]

, 2008
In this paper we formulate and explore a mathematical model to study continuous infusion of a vascular tumour with isolated and combined blood-borne chemotherapies.
Jasmina Panovska, Helen M. Byrne, Philip K. Maini, Casciari, Sutherland, Muthukkaruppan, Baptist-Trimbos, Cheng, Stoll, Rowinsky, Sherratt, Ward, Gatenby, Sherratt, Anderson, Byrne, Orme, Orme, Breward, Breward, Hahnfield, d’Onfrio, Panovska, Griffiths, De Angelis, Baxter, Sholley, O’Reilly, O’Reilly, West, Ward, Jackson, Arakelyn, Agur, Sinek, Zheng, Fister, Fister, Balding, Edelstein, Stokes, Press, Degregorio, Jackson, Dordel, Jackson, Laderoute, Pettet   +47 more
core   +2 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Red Blood Cell Parameters of Healthy Centenarians.

Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 1995
Since the number of centenarians is increasing rapidly in recent years, the establishment of normal ranges in red blood cell (RBC) parameters for healthy centenarians is necessary for diagnostic criteria of anemia. The subjects were 129 centenarians consisting of 27 men (17; healthy, 69; low ADL) and 102 women (33; healthy, 69; low ADL) after excluding
H, Nozaki, I, Ashitomi, K, Higa, M, Akisaka, M, Suzuki   +4 more
openaire   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Central Monitor Based on Personal Computer Using Single Wireless Receiver [PDF]

, 2019
Central monitor is a tool that monitors the patient's condition with several devices into one display on a personal computer (PC). Pulse Oxymetri serves to monitor the state of oxygen saturation in the patient's blood without going through blood gas ...
Fanani, A. (Ahmad), Irianto, B. G. (Bambang), Pudji, A. (Andjar)   +2 more
core  

Efficacy of Probiotic Lactobacillus spp. Isolated From Healthy Korean Indigenous Calves

Veterinary Medicine and Science
Background A healthy gut microbiota enhances immune function and reduces infection susceptibility in neonatal calves. Objectives This study evaluated the probiotic efficacy of Lactobacillus amylovorus, Lactobacillus reuteri and Lactobacillus johnsonii ...
Ji‐Yeong Ku, Mi‐Jin Lee, Youngwoo Jung, Youngjun Kim, Kwang‐Man Park, Jonghun Baek, Byoungsoo Kim, Ji‐Seon Yoon, Jinho Park   +8 more
doaj   +1 more source