Results 71 to 80 of about 602,192 (314)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Parameter identification for a one-dimensional blood flow model [PDF]

, 2004
International audienceThe purpose of this work is to use a variational method to identify some of the parameters of one-dimensional models for blood flow in arteries.
Clément, François, Vincent Martin, Astrid Decoene, Gerbeau, Jean-Frédéric, Martin, Vincent, Jean-Frédéric Gerbeau, Decoene, Astrid, Francois Clément   +7 more
core   +1 more source

Rabbit dietary supplementation with pale purple coneflower. 2. Effects on the performances, bacterial community, blood parameters and immunity of growing rabbits

Animal, 2016
Echinacea pallida (EPAL), a herbaceous flowering plant with immunomodulatory properties, has been chosen to determine the pre- and post-supplementary effects on the growth performances, bacterial community, blood parameters and immunity of growing ...
A. Kovitvadhi, F. Gai, S. Dabbou, I. Ferrocino, L. Rotolo, M. Falzone, C. Vignolini, M.S. Gennero, S. Bergagna, Daniela Dezzutto, R. Barbero, P. Nebbia, S. Rosati, L. Cocolin, I. Zoccarato, L. Gasco   +15 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

"In vitro" evaluation of blood-brain barrier transport [PDF]

, 2014
The blood-brain barrier (BBB), which is formed by brain capillary endothelial cells, effectively protects the central nervous system (CNS) from potential neurotoxic agents and maintains the brain homeostasis for synaptic signaling (Abbott, 2004 ...
Dieu, Le-Ha
core   +1 more source

Impact of adding zeolite to broilers' diet and litter on growth, blood parameters, immunity, and ammonia emission

Poultry Science
: This work was designed to assess the impact of varying zeolite concentrations in diet and litter to enhance broiler's growth performance, immunity, and litter quality.
Ahmed I. Elsherbeni, Islam M. Youssef, Mahmoud Kamal, Mai A.M. Youssif, Gaafar M. El-Gendi, Osama H. El-Garhi, Haifa E. Alfassam, Hassan A. Rudayni, Ahmed A. Allam, Mahmoud Moustafa, Mohammed O. Alshaharni, Mohammed Al-Shehri, Mohamed S. El Kholy, Reda E. Hamouda   +13 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Positron emission tomography compartmental models: A basis pursuit strategy for kinetic modelling

, 2002
A kinetic modelling approach for the quantification of in vivo tracer studies with dynamic positron emission tomography (PET) is presented. The approach is based on a general compartmental description of the tracer’s fate in vivo and determines a ...
Roger N. Gunn, Gunn, S R, Turkheimer, F E ; id_orcid, Aston, J A D, John A. D. Aston, Cunningham, T J, Turkheimer, F.E., Aston, J.A.D., Gunn, S.R., Gunn, R.N., Federico E. Turkheimer, Steve R. Gunn, Vincent J. Cunningham, Cunningham, V.J., Gunn, R N   +14 more
core   +1 more source

Is Stryd critical power a meaningful parameter for runners?

, 2022
Stryd is a foot pod that reliably estimates running power. Our objectives were to examine the efficacy of the website-generated Stryd critical power (CPSTRYD) as a meaningful parameter for runners.
Chey G. Dearing, Carl D. Paton
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source