Results 1 to 10 of about 8,163,421 (306)

Formation of a protein corona on the surface of extracellular vesicles in blood plasma

Journal of Extracellular Vesicles, 2021
In this study we tested whether a protein corona is formed around extracellular vesicles (EVs) in blood plasma. We isolated medium‐sized nascent EVs of THP1 cells as well as of Optiprep‐purified platelets, and incubated them in EV‐depleted blood plasma ...
Eszter Á. Tóth, Lilla Turiák, T. Visnovitz, C. Cserép, A. Mázló, Barbara W. Sódar, András I. Försönits, G. Petővári, A. Sebestyén, Z. Komlósi, L. Drahos, Á. Kittel, G. Nagy, A. Bácsi, Á. Dénes, Y. Gho, K. Szabó-Taylor, E. Buzás   +17 more
semanticscholar   +1 more source

Removal of platelets from blood plasma to improve the quality of extracellular vesicle research

Journal of Thrombosis and Haemostasis, 2022
Blood plasma is commonly used for biomarker research of extracellular vesicles (EVs). Removing all cells prior to analysis of EVs is essential.
Britta A Bettin, A. Gąsecka, Bo Li, Bert Dhondt, A. Hendrix, R. Nieuwland, Edwin van der Pol   +6 more
semanticscholar   +1 more source

Primary plasma cell leukemia: consensus definition by the International Myeloma Working Group according to peripheral blood plasma cell percentage

Blood Cancer Journal, 2021
Primary plasma cell leukemia (PCL) has a consistently ominous prognosis, even after progress in the last decades. PCL deserves a prompt identification to start the most effective treatment for this ultra-high-risk disease.
C. Fernández de Larrea, R. Kyle, L. Rosiñol, B. Paiva, M. Engelhardt, S. Usmani, J. Caers, W. Gonsalves, Fredrik H. Schjesvold, G. Merlini, Suzanne Lentzch, E. Ocio, L. Garderet, P. Moreau, P. Sonneveld, A. Badros, G. Gahrton, H. Goldschmidt, S. Tuchman, H. Einsele, B. Durie, B. Wirk, P. Musto, P. Hayden, M. Kaiser, J. Miguel, J. Bladé, S. Rajkumar, M. Mateos   +28 more
semanticscholar   +1 more source

Robust sequential biophysical fractionation of blood plasma to study variations in the biomolecular landscape of systemically circulating extracellular vesicles across clinical conditions

Journal of Extracellular Vesicles, 2021
Separating extracellular vesicles (EV) from blood plasma is challenging and complicates their biological understanding and biomarker development. In this study, we fractionate blood plasma by combining size‐exclusion chromatography (SEC) and OptiPrep ...
Glenn Vergauwen, Joeri Tulkens, Cláudio Pinheiro, Francisco Avila Cobos, Sándor Dedeyne, Marie-Angélique De Scheerder, L. Vandekerckhove, Francis Impens, I. Miinalainen, G. Braems, K. Gevaert, P. Mestdagh, J. Vandesompele, H. Denys, O. De Wever, A. Hendrix   +15 more
semanticscholar   +1 more source

Blood plasma phosphorylated-tau isoforms track CNS change in Alzheimer’s disease

Journal of Experimental Medicine, 2020
Barthélemy et al. use mass spectrometry to characterize plasma tau isoforms and assess their diagnosis utility for Alzheimer’s disease. They demonstrate plasma tau phosphorylation measures of p-tau-217 and p-tau-181 are increased with amyloid.
N. Barthélemy, Kanta Horie, C. Sato, R. Bateman   +3 more
semanticscholar   +1 more source

Low Doses of LSD Acutely Increase BDNF Blood Plasma Levels in Healthy Volunteers

ACS Pharmacology & Translational Science, 2020
Despite preclinical evidence for psychedelic-induced neuroplasticity, confirmation in humans is grossly lacking. Given the increased interest in using low doses of psychedelics for psychiatric indications and the importance of neuroplasticity in the ...
N. Hutten, N. Mason, P. Dolder, E. Theunissen, F. Holze, M. Liechti, N. Varghese, A. Eckert, A. Feilding, J. Ramaekers, K. Kuypers   +10 more
semanticscholar   +1 more source

Circulating free fatty acids, insulin, and glucose during chemical stimulation of hypothalamus in rats [PDF]

, 1984
The aim of this study was to investigate plasma free fatty acids (FFA), insulin, and blood glucose during chemical stimulation of the lateral and ventromedial hypothalamic areas (LHA and VMH) in rats.
Damsma, G.,, Gugten, J. van der,, Luiten, P.G.M.,, Steffens, A.B.,   +3 more
core   +1 more source

Blood rheology, cardiovascular risk factors, and cardiovascular disease: The West of Scotland Coronary Prevention Study [PDF]

, 2000
The West of Scotland Coronary Prevention Study (WOSCOPS) showed that pravastatin reduced the risk of coronary heart disease (CHD) events in 6,595 middle-aged hypercholesterolaemic men aged 45-64 years without prior myocardial infarction followed for an ...
Ann Rumley, Christopher Packard, Gordon Lowe, Ian Ford, James Shepherd, John Norrie, null null, Peter Macfarlane, Stuart Cobbe   +8 more
core   +1 more source

Seminal Plasma Proteins [PDF]

, 2012
The ejaculated semen consists of two major components viz. sperm cells (spermatozoa) and the fluid part obtained after centrifugation called seminal plasma.
P Perumal
core   +2 more sources

Self-powered microfluidic chips for multiplexed protein assays from whole blood [PDF]

, 2009
We report herein on a self-powered, self-contained microfluidic-based chip designed to separate plasma from whole blood, and then execute an assay of a multiplexed panel of plasma biomarker proteins.
Heath, James R., Qin, Lidong, Shi, Qihui, Vermesh, Ophir   +3 more
core   +2 more sources