Results 51 to 60 of about 227,900 (303)

Evaluation of Platelet and Leukocyte Counts in Canine Platelet-Rich Plasma Obtained After Successive Blood Collections From the Same Patient and the Effects of Freezing on the Concentration of Growth Factors Present in It

Frontiers in Veterinary Science, 2022
ObjectiveThe purpose of this study was 2-fold: to evaluate whether the timing of collection influences the platelet counts and leukocyte counts of PRP samples, and to evaluate growth factor concentrations in canine PRP after freezing and storage without ...
Victoria DeMello, Grace Chen, Joseph Wakshlag, David Mason   +3 more
doaj   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

Prognosis of Long‐Term Continuous Renal Replacement Therapy and the Impact of Combined Continuous Intravenous Sodium Infusion Therapy

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Patients requiring long‐term continuous renal replacement therapy (CRRT) generally have poor prognoses. This study evaluated whether adding continuous intravenous sodium infusion (cIVNa) is associated with improved hemodynamics and outcomes in patients undergoing long‐term CRRT for ≥ 7 days.
Akinori Yamaguchi, Atsuyoshi Mita, Kosuke Sonoda, Makoto Harada, Koji Hashimoto, Hiroshi Imamura, Yuji Kamijo   +6 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Platelet kinetics in the pulmonary microcirculation in vivo assessed by intravital microscopy [PDF]

, 2002
Growing evidence supports the substantial pathophysiological impact of platelets on the development of acute lung injury. Methods for studying these cellular mechanisms in vivo are not present yet.
Eichhorn, M. E., Ney, L., Massberg, S., Goetz, Alwin Eduard   +3 more
core   +1 more source

Establishment of internal quality control methodology for blood transfusion compatibility testing

Zhongguo shuxue zazhi
Objective To monitor the effectiveness and accuracy of the blood transfusion compatibility test system by self-made weakly positive internal quality control products.
Lu LI, Xiaolin SUN, Junjie WEI, Ruiqi LIU, Weixin WU, Haiyun Liu, Yinze ZHANG   +6 more
doaj   +1 more source

Subnormothermic Perfusion with H₂S Donor AP39 Improves DCD Porcine Renal Graft Outcomes in an Ex Vivo Model of Kidney Preservation and Reperfusion

Biomolecules, 2021
Cold preservation is the standard of care for renal grafts. However, research on alternatives like perfusion at higher temperatures and supplementing preservation solutions with hydrogen sulfide (H2S) has gained momentum.
Smriti Juriasingani, Aushanth Ruthirakanthan, Mahms Richard-Mohamed, Masoud Akbari, Shahid Aquil, Sanjay Patel, Rafid Al-Ogaili, Matthew Whiteman, Patrick Luke, Alp Sener   +9 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Interleukin-1 regulates multiple atherogenic mechanisms in response to fat feeding [PDF]

, 2009
Background: Atherosclerosis is an inflammatory process that develops in individuals with known risk factors that include hypertension and hyperlipidaemia, influenced by diet.
Dower, S., Zoe Brookes, Nicholas J Alp, Francis, Sheila, Steven Dower, David C Crossman, Brookes, Zoe, Francis, S., Shaw, Gary, Shaw, G., Crossman, D.C., Gary Shaw, Sheila Francis, Graham, Delyth, Brookes, Z., Alp, N.J., Crossman, David C., Chamberlain, J., Delyth Graham, Dower, Steven, Graham, D., Xu, A., Janet Chamberlain, Alp, Nicholas J., Xu, Aimin, Chamberlain, Janet   +25 more
core   +1 more source