Results 51 to 60 of about 568,558 (313)

Preservation of blood form elements under the protection of combined cryopreservative during low-temperature freezing

Siberian Journal of Life Sciences and Agriculture
Background. Cryopreservation has found wide application for various purposes but the disadvantages of existing cryoprotective agents lead to the loss of cell functionality, which can negatively affect the further use of preserved material.
Aleksandr A. Vlasov, Svetlana F. Andrusenko, Evgeniya V. Denisova, Aishat B. Elkanova, Dmitry A. Bogoslovsky, Inna V. Sivun   +5 more
doaj   +1 more source

The adverse impact on liver transplantation of using positive cytotoxic crossmatch donors [PDF]

, 1992
Because of the liver graft's ability to resist cytotoxic antibody-mediated rejection, it has become dogma that the conventional transplant crossmatch used to avoid hyperacute rejection of other organs is irrelevant to the liver.
Abu-Elmagd, K, Bronsther, O, Demetris, AJ, Fung, JJ, Iwaki, Y, Kobayashi, M, Nakamura, K, Starzl, TE, Takaya, S, Todo, S, Tzakis, AG, Yagihashi, A   +11 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Minimally invasive distal pancreatectomy: Laparoscopic versus robotic approach—A cohort study

Health Science Reports, 2022
Background and Aims There is no consensus on the superiority of robotic distal pancreatectomy (RDP) over laparoscopic distal pancreatectomy (LDP). Methods Data of patients undergoing RDP and LDP were prospectively collected and compared.
Hon‐Fan Lai, Yi‐Ming Shyr, Bor‐Shiuan Shyr, Shih‐Chin Chen, Shin‐E Wang, Bor‐Uei Shyr   +5 more
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Monitoring kidney optical properties during cold storage preservation with spatial frequency domain imaging. [PDF]

, 2019
Transplantation of kidneys results in delayed graft function in as many as 40% of cases. During the organ transplantation process, donor kidneys undergo a period of cold ischemic time (CIT), where the organ is preserved with a cold storage solution to ...
Durkin, Anthony, Ichii, Hirohito, Jarrin Lopez, Alberto, Li, Shiri, Li, Xiaodong, Ponticorvo, Adrien, Rowland, Rebecca   +6 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A novel technique for isolating DNA from Tempus™ blood RNA tubes after RNA isolation

BMC Research Notes, 2018
Objective We use Tempus blood RNA tubes (Applied Biosystems) during health assessments of American moose (Alces alces spp.) as a minimally invasive means to obtain RNA.
Jason A. Ferrante, Michelle R. Giles, Emily Benzie, Margaret E. Hunter   +3 more
doaj   +1 more source

A clinicopathological study of human liver allograft recipients harboring preformed IgG lymphocytotoxic antibodies [PDF]

, 1992
Twenty‐six adult patients with preformed IgG donor lymphocytotoxic antibodies received primary liver allografts under FK 506 immunosuppression. The effect of the crossmatch‐positive state on early graft function and on the immunopathological and ...
Batts, Bird, Busch, Cerilli, Demetris, Demetris, Demetris, Dempster, Donaldson, Eggink, Giles, Gordon, Gubernatis, Gugenheim, Gugenheim, Hanto, Houssin, Ito, Iwaki, Iwatsuki, Kakizoe, Kissmeyer-Nielsen, Knechtle, Okuno, Simpson, Snover, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Takaya, Takaya, Takaya, Terada, Terasaki, Todo, Weber, Williams   +40 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source