Results 71 to 80 of about 227,900 (303)

SEPARATION OF LEUCOCYTES FROM PERIPHERAL BLOOD OF DOGS [PDF]

Assiut Veterinary Medical Journal, 1985
In the present study, an efficient method for separation, concentration and preservation of dog leucocytes from the peripheral blood were described. Statistical methods were carried out to postulate the chan ges in each test done.
A.Z. MAHMOUD, M.K. IBRAHIM, A.H. BAYOUMI
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

A novel technique for isolating DNA from Tempus™ blood RNA tubes after RNA isolation

BMC Research Notes, 2018
Objective We use Tempus blood RNA tubes (Applied Biosystems) during health assessments of American moose (Alces alces spp.) as a minimally invasive means to obtain RNA.
Jason A. Ferrante, Michelle R. Giles, Emily Benzie, Margaret E. Hunter   +3 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Preservation of major depression enriched network modules across brain tissues and whole blood.

, 2019
(A) Preservation Z score for tissue-specific modules (labelled M1 to M6 on the y axis) across brain tissues and whole blood. A higher Z score indicates greater preservation (i.e. replication) of a “reference” network in a “test” network (and vice versa).
Zachary F. Gerring (6954416), Eric R. Gamazon (125324), Eske M. Derks (156071)   +2 more
core   +1 more source

A comparison of human blood preservation methods in DNA extraction protocol

, 2022
Background: Blood preservation method plays an important role in DNA extraction. The current study was conducted at the laboratories of the applied medical sciences college/ University of Karbala during the period from March to May 2021.Materials: Ten ...
Aedan, Raghda Haider, Gaaib, Jawdat Noori, Juda, Zainab Waad   +2 more
core   +1 more source

Improved maternal outcome in placenta accreta spectrum disorders: a single-institute observational cohort study

BMC Pregnancy and Childbirth
Background To describe the evolution and outcomes of protocol-orientated multidisciplinary quality improvement for clinically confirmed placenta accreta spectrum (PAS) disorders mainly receiving uterine preservation.
Hang Zhou, Wenwen Wang, Ning Gu, Qiang Li, Lili Qiu, Zhenhua Zhu, Zhiqun Wang, Yimin Dai   +7 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

The Identification and Preservation of a Blood Impression on Skin

, 1976
The finding, identification and preservation of a palm mark in blood on human skin may or may not be unique. I am aware that a “latent” impression was developed on skin some years ago under laboratory conditions but the chance of this being accomplished
P. M. Swann
core   +1 more source