Results 61 to 70 of about 227,900 (303)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Effect of praziquantel treatment of Schistosoma mansoni during pregnancy on immune responses to schistosome antigens among the offspring: results of a randomised, placebo-controlled trial. [PDF]

, 2011
BACKGROUND: Offspring of women with schistosomiasis may exhibit immune responsiveness to schistosomes due to in utero sensitisation or trans-placental transfer of antibodies.
Webb, Emily L, Emily L Webb, Dunne, David W, Dunne, David W., Tweyongyere, Robert, Mawa, Patrice A, Birgitte J Vennervald, David W Dunne, Jones, Frances M., Webb, Emily L., Elliott, Alison M., Patrice A Mawa, Vennervald, Birgitte J, Frances M Jones, Stephen Cose, Kihembo, Macklyn, Alison M Elliott, Cose, Stephen, Macklyn Kihembo, Elliott, Alison M, Robert Tweyongyere, Jones, Frances M, Mawa, Patrice A.   +22 more
core   +1 more source

Zwitterionic microgel preservation platform for circulating tumor cells in whole blood specimen

, 2023
The immediate processing of whole blood specimen is required in circulating tumor cell-based liquid biopsy. Reliable blood specimen stabilization towards preserving circulating tumor cells can enable more extensive geographic sharing for precise rare ...
Jun Zhang, Yihao Fu, Qingsi Li, Yiming Ma, Shu Tian, Jing Yang, Lei Zhang, Yunqing Tian   +7 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Preservation of blood form elements under the protection of combined cryopreservative during low-temperature freezing

Siberian Journal of Life Sciences and Agriculture
Background. Cryopreservation has found wide application for various purposes but the disadvantages of existing cryoprotective agents lead to the loss of cell functionality, which can negatively affect the further use of preserved material.
Aleksandr A. Vlasov, Svetlana F. Andrusenko, Evgeniya V. Denisova, Aishat B. Elkanova, Dmitry A. Bogoslovsky, Inna V. Sivun   +5 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Impact of preservation solution on the extent of blood-air barrier damage and edema formation in experimental lung transplantation

, 2007
A major aim in lung transplantation is to prevent the loss of structural integrity due to ischemia and reperfusion (I/R) injury. Preservation solutions protect the lung against I/R injury to a variable extent.
Katharina Müller, Richter, Joachim, Mühlfeld, Christian, Wittwer, Thorsten, Lars‐Peder Pallesen, Christian Mühlfeld, Tim Sandhaus, Pallesen, Lars-Peder, Thorsten Wittwer, Madershahian, Navis, Thorsten Wahlers, Matthias Ochs, Ochs, Matthias, Wahlers, Thorsten, Navis Madershahian, Sandhaus, Tim, Joachim Richter, Müller, Katharina   +17 more
core   +1 more source

Factors affecting the infant antibody response to measles immunisation in Entebbe-Uganda. [PDF]

, 2013
BACKGROUND: Vaccine failure is an important concern in the tropics with many contributing elements. Among them, it has been suggested that exposure to natural infections might contribute to vaccine failure and recurrent disease outbreaks.
Webb, Emily L, Emily L Webb, Tweyongyere, Robert, Bukenya, Henry, Muhangi, Lawrence, Lawrence Muhangi, Swaib A Lule, Stephen Cose, Lule, Swaib A, Alice Namatovu, Alison M Elliott, Namatovu, Alice, Cose, Stephen, Dennison Kizito, Elliott, Alison M, Robert Tweyongyere, Kizito, Dennison, Henry Bukenya   +17 more
core   +1 more source