Results 91 to 100 of about 10,778,146 (402)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Novel biomarkers in patients with uncontrolled hypertension with and without kidney damage

Blood Pressure
Introduction Estimated glomerular filtration rate (eGFR) and urine albumin/creatinine ratio (ACR) are insensitive biomarkers for early detection of hypertension-mediated organ damage (HMOD). In this nationwide cross-sectional study, we assessed potential
Karl Marius Brobak, Lene V. Halvorsen, Hans Christian D. Aass, Camilla L. Søraas, Arleen Aune, Eirik Olsen, Ola Undrum Bergland, Stine Rognstad, Kjersti B. Blom, Jon Arne K. Birkeland, Aud Høieggen, Anne Cecilie K. Larstorp, Marit D. Solbu   +12 more
doaj   +1 more source

Blood pressure response to renal denervation is correlated with baseline blood pressure variability: a patient-level meta-analysis [PDF]

, 2018
Background: Sympathetic tone is one of the main determinants of blood pressure (BP) variability and treatment-resistant hypertension. The aim of our study was to assess changes in BP variability after renal denervation (RDN).
Berra, Elena, Blankestijn, Peter J., Bots, Michiel L., Burnier, Michel, Czarnecka, Danuta, de Jong, Mark R., Elvan, Arif, Fadl Elmula, Fadl Elmula M., Gordin, Daniel, Jacobs, Lotte, Kahan, Thomas, Kjeldsen, Sverre E., Mark, Patrick B., Miroslawska, Atena, Olszanecka, Agnieszka, Persu, Alexandre, Renkin, Jean, Rosa, Ján, Spaak, Jonas, Spiering, Wilko, Staessen, Jan A., Steigen, Terje K., Taylor, Alison H.M., the European Network COordinating research on Renal Denervation (ENCOReD), Thijs, Lutgarde, Tikkanen, Ilkka, Widimský, Jiří, Wuerzner, Gregoire   +27 more
core   +2 more sources

Relation between blood pressure and pulse wave velocity for human arteries

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Continuous, cuffless, and noninvasive blood pressure monitoring by measuring the pulse wave velocity is generally considered to be a promising technique for noninvasive measurements.
Yinji Ma, Jungil Choi, A. Hourlier-Fargette, Yeguang Xue, Ha Uk Chung, Jong Yoon Lee, Xiufeng Wang, Zhaoqian Xie, Daeshik Kang, Heling Wang, Seungyong Han, Seung‐Kyun Kang, Yisak Kang, Xinge Yu, M. Slepian, M. Raj, Jeffrey B. Model, Xue Feng, R. Ghaffari, J. Rogers, Yonggang Huang   +20 more
semanticscholar   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Improving blood pressure and dyslipidemia control by increasing health literacy in Croatia-missions 70/26 & Do you know what is your number

Blood Pressure
Purpose In 2022 hypertensive disease was the second cause of death in Croatia. The crude prevalence of hypertension is increasing and still majority of hypertensive patients did not reach blood pressure and cholesterol goals Low awareness, and small ...
Bojan Jelaković, Ivan Pećin, Valerija Bralić Lang, Marijana Braš, Krunoslav Capak, Ana Jelaković, Verica Kralj, Davor Miličić, Ana Soldo, Marija Bubaš   +9 more
doaj   +1 more source

Cardiovascular Risk Reduction After Renal Denervation According to Time in Therapeutic Systolic Blood Pressure Range

, 2022
Felix Mahfoud, Giuseppe Mancia, Roland E. Schmieder, Luís M. Ruilope, Krzysztof Narkiewicz, Markus P. Schlaich, Bryan Williams, Flavio Ribichini, Joachim Weil, Hsien‐Li Kao, Oriol Rodríguez‐Leor, Elias Noory, Tiong Kiam Ong, Thierry Unterseeh, Pedro de Araújo Gonçalves, Andreas Zirlik, Khaled Almerri, Faisal Sharif, Lucas Lauder, Marianne Wanten, Martin Fahy, Michael Böhm   +21 more
openalex   +1 more source

Genetic Variants in Novel Pathways Influence Blood Pressure and Cardiovascular Disease Risk

Nature, 2011
Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm Hg systolic blood pressure or ≥90 mm Hg diastolic blood pressure).
George B. Ehret, Georg Benedikt
semanticscholar   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The association between serum folate and elderly diastolic hypertension: results from the NHANES (2007–2018)

Blood Pressure
Aim To explore the association between serum folate concentration and the prevalence of elderly diastolic hypertension. This study aims to identify potential relationships that could inform further research into the mechanisms underlying hypertension ...
Hong Xie, Xiao-Feng Fan, Wen-Huan Shuai, Gui-You Zhong   +3 more
doaj   +1 more source